Figure 1
From: The mast cell integrates the splanchnic and systemic inflammatory response in portal hypertension
Alterations related to prehepatic portal hypertension in the rat, where mast cells and their mediators could participate in its production. The systemic inflammatory response would integrate splanchnic alterations (portal hypertensive enteropathy, hepatic steatosis, splenomegaly and portosystemic collateral circulation) with extrasplanchnic alterations (portal hypertensive encephalopathy).