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Table 3 DC-specific genes that are over-expressed in spleen of Immune Mice. Values within square brackets [] represent the fold increase in the expression of each gene by mice vaccinated with semi-allogeneic vaccines compared to mice mock-vaccinated with PBS. These over-expressed genes are in addition to those listed in Table 1.

From: Semi-allogeneic vaccine for T-cell lymphoma

DC-SIGN [4.0] (CD209a)

A cell surface C-type lectin expressed by dendritic cells that mediates antigen capture for processing and presentation

CD28 [1.6]

T cell-specific receptor for CD80 and CD86

CD83 [1.9]

The most reliable activation marker for mature dendritic cells

FAS [2.1]

The apoptosis-mediating membrane-associated polypeptide that belongs to the tumor necrosis factor receptor superfamily

Flt3L [1.7]

A ligand that expands type-1 dendritic cells and enhances the immune response by augmenting T-cell activity

H2-DMa [2.0]

Involved in antigen processing and presentation of exogenous peptide antigens via MHC class II

ICOSL [2.6] (B7-H2)

Is a ligand for T cell-specific, cell surface receptor ICOS and acts as a co-stimulatory signal for T-cell proliferation and cytokine secretion

CD11c [1.7] (ITGAX)

Expressed by dendritic cells that tend to generate Th1 effectors

LTA [1.7] (TNF-β)

Lymphotoxin α or tumor necrosis factor β

NFKB [1.5]

A transcription factor required for STAT-4 expression during dendritic cell maturation

XCL1 [2.5] (ATAC)

An activation-induced, T cell-derived and chemokine-related type 1 cytokine, that cooperates with interferon (IFN)-γ in the up-regulation of CD40 and interleukin (IL)-12 expression