Molecular purging of multiple myeloma cells by ex-vivo culture and retroviral transduction of mobilized-blood CD34+ cells

Table 3 Statistical comparison of tumor load between different cell populations

	ESTIMATED DECREASE (RATIO)	95% CONFIDENCE	INTERVAL	P VALUE
CD34 ⁺ fresh cells versus CD34 ⁺ cells after culture	6.86	1.75	27.17	5.78 × 10^-3
CD34 ⁺ fresh cells versus ΔNGFR ⁺ selected cells	16.98	5.54	52.04	8.29 × 10^-7
CD34 ⁺ after culture versus ΔNGFR ⁺ selected cells	2.46	0.43	14.15	3.12 × 10^-1

The amount of purging was evaluated in different coupled cell populations, and expressed as ratio of contaminant tumor cells (number of tumor cells pre purging/number of tumor cells after purging).

ISSN: 1479-5876