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Table 1 Comparison of levels of soluble protein biomarkers (VEGF, sVEGFR-2, and PlGF) at baseline and at the end of the first treatment cycle (day 28 of cycle 1) in RCC patients. Only readings that were in the assay detection range are included in this table.

From: Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins

  Mean Median Range (pg/mL)
VEGF    
Cycle 1, Day 1 (n = 62) 86.9 67.0 9.7 – 355.5
Cycle 1, Day 28 (n = 55) 278.7 193.3 26.1 – 973.9
sVEGFR-2    
Cycle 1, Day 1 (n = 62) 9610.3 9554.5 6390 – 14496.5
Cycle 1, Day 28 (n = 57) 5303.9 5157.0 1948 – 11241.5
PlGF*    
Cycle 1, Day 1 (n = 17) 41.7 35.6 26.7 – 95.9
Cycle 1, Day 28 (n = 53) 111.8 77.9 29.0 – 483.3