Figure 4

Fold-changes (ratios to baseline) in mean plasma levels of VEGF and PlGF at different trough levels (x-axis), indicative of a threshold effect. Fold-change values shown are from cycle 1, day 28 over baseline (cycle 1, day 1). *X-axis categories refer to ranges of combined trough drug levels at day 28 of cycle 1 (in ng/mL); **For PIGF, many of the fold-change values are minimum estimates; values below the lower limit of quantification (LLQ) were assigned value equivalent to the LLQ (26.2 pg/mL)