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Table 1 Phenotypic analysis of peripheral blood mononuclear cells during treatment with Alefacept.

From: Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis

Cell type

Phenotypic marker

D0

Wk 13

Percent change

P value

   

T cell

CD3+

1474

967

-34.0

<10-4

   

Memory T cell

CD3+ CD45RA-

900

467

-48.0

<10-4

   

B cell

CD19+

211

198

-6.0

0.65

   

NK cell

CD56+ CD16+ CD3-

125

130

4.0

0.78

   

Naïve CD4+

CD4+ CD45RA+

247

236

-5.0

0.60

   

Memory CD4+

CD4+ CD45RO+

484

290

-40.0

0.0005

   

Naïve CD8+

CD8+ CD27+ CD45RA+

166

135

-19.0

0.025

   

Memory CD8+

CD8+ CD27+ CD45RA-

164

57

-65.0

<10-4

   

Effector CD8+

CD8+ CD27- CD45RA+

21

14

-32.0

0.015

   

CD4+ CD25+ T cells

CD4+ CD25+

525

365

-30.0

0.0124

   

Skin-homing CD4+

CD4+ CLA+

86

44

-49.0

0.0012

   

Skin-homing CD8+

CD8+ CLA+

23

12

-48.0

0.009

   

Epithelial-homing CD8+

CD8+ CD103+

17

5

-70.0

<10-4

   

VLA-4lo

CD8+ CD49dlo

172

132

-23.0

0.002

   

VLA-4hi

CD8+ CD49dhi

226

97

-57.0

<10-4

   

LFA-1lo

CD8+ CD11alo

201

155

-23.0

0.018

   

LFA-1hi

CD8+ CD11ahi

202

80

-61.0

<10-4

   

Memory T cell subsets

Phenotypic marker

D0

Wk 13

Percent change

P value

CD2 MFI D0

CD2 MFI Wk 13

P value

Naïve CD4+

CD4+ CCR7+ CD45RA+

216

220

2.0

0.88

90

88

0.49

Tcm CD4+

CD4+ CCR7+ CD45RA-

377

274

-27.0

0.0135

141

119

0.0002

Tem CD4+

CD4+ CCR7- CD45RA-

179

67

-63.0

<10-4

198

146

<10-4

Naïve CD8+

CD8+ CCR7+ CD45RA+

75

78

4.0

0.76

127

120

0.20

Tcm CD8+

CD8+ CCR7+ CD45RA-

48

25

-47.0

<10-4

192

159

0.003

Tem CD8+

CD8+ CCR7- CD45RA-

110

40

-63.0

<10-4

233

190

0.002

Effector CD8+

CD8+ CCR7- CD45RA+

102

51

-50.0

0.0001

178

131

0.0002

  1. Geometric mean absolute cell number per μl circulating blood at baseline (D0, day 0) and post treatment (week 13). Percent change is calculated by [(week 13-week 0)/week 0 as a %]. CD2 mean fluorescence intensity (MFI) of memory cell subsets. P value comparing week 0 and week 13.