Cell type | Phenotypic marker | D0 | Wk 13 | Percent change | P value | |||
---|---|---|---|---|---|---|---|---|
T cell | CD3+ | 1474 | 967 | -34.0 | <10-4 | |||
Memory T cell | CD3+ CD45RA- | 900 | 467 | -48.0 | <10-4 | |||
B cell | CD19+ | 211 | 198 | -6.0 | 0.65 | |||
NK cell | CD56+ CD16+ CD3- | 125 | 130 | 4.0 | 0.78 | |||
Naïve CD4+ | CD4+ CD45RA+ | 247 | 236 | -5.0 | 0.60 | |||
Memory CD4+ | CD4+ CD45RO+ | 484 | 290 | -40.0 | 0.0005 | |||
Naïve CD8+ | CD8+ CD27+ CD45RA+ | 166 | 135 | -19.0 | 0.025 | |||
Memory CD8+ | CD8+ CD27+ CD45RA- | 164 | 57 | -65.0 | <10-4 | |||
Effector CD8+ | CD8+ CD27- CD45RA+ | 21 | 14 | -32.0 | 0.015 | |||
CD4+ CD25+ T cells | CD4+ CD25+ | 525 | 365 | -30.0 | 0.0124 | |||
Skin-homing CD4+ | CD4+ CLA+ | 86 | 44 | -49.0 | 0.0012 | |||
Skin-homing CD8+ | CD8+ CLA+ | 23 | 12 | -48.0 | 0.009 | |||
Epithelial-homing CD8+ | CD8+ CD103+ | 17 | 5 | -70.0 | <10-4 | |||
VLA-4lo | CD8+ CD49dlo | 172 | 132 | -23.0 | 0.002 | |||
VLA-4hi | CD8+ CD49dhi | 226 | 97 | -57.0 | <10-4 | |||
LFA-1lo | CD8+ CD11alo | 201 | 155 | -23.0 | 0.018 | |||
LFA-1hi | CD8+ CD11ahi | 202 | 80 | -61.0 | <10-4 | |||
Memory T cell subsets | Phenotypic marker | D0 | Wk 13 | Percent change | P value | CD2 MFI D0 | CD2 MFI Wk 13 | P value |
Naïve CD4+ | CD4+ CCR7+ CD45RA+ | 216 | 220 | 2.0 | 0.88 | 90 | 88 | 0.49 |
Tcm CD4+ | CD4+ CCR7+ CD45RA- | 377 | 274 | -27.0 | 0.0135 | 141 | 119 | 0.0002 |
Tem CD4+ | CD4+ CCR7- CD45RA- | 179 | 67 | -63.0 | <10-4 | 198 | 146 | <10-4 |
Naïve CD8+ | CD8+ CCR7+ CD45RA+ | 75 | 78 | 4.0 | 0.76 | 127 | 120 | 0.20 |
Tcm CD8+ | CD8+ CCR7+ CD45RA- | 48 | 25 | -47.0 | <10-4 | 192 | 159 | 0.003 |
Tem CD8+ | CD8+ CCR7- CD45RA- | 110 | 40 | -63.0 | <10-4 | 233 | 190 | 0.002 |
Effector CD8+ | CD8+ CCR7- CD45RA+ | 102 | 51 | -50.0 | 0.0001 | 178 | 131 | 0.0002 |