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Table 10 Individual pp65 Epitopes that Induced intracellular IFN-γ Production by CD4+ T Cells, the HLA Type of Donors With Reactive CD4+ T Cells, and the HLA Antigen Restriction of Each Epitope

From: CMV pp65 and IE-1 T cell epitopes recognized by healthy subjects

Peptide(s) Donor DRB1* DRB- DQB1* HLA Antigen Restriction Published Antigen Restriction
  12 03021, 1503 3*01, 5*01 06 DRB1*15 or DRB5*01 pp65225–239 DR15 [23]
pp65221–235 08 13031, 1503 3*02, 3*02 02, 06   
  10 0701, 1302 3*0301, 4*0401 0202, 0604 No cells available  
pp65285–299 07 0401, 0701 4*01, 4*01 0303, 03 No cells available pp65281–295 DR4, 7 [11]
pp65365–379 01 0901, 11 3*00, 4*01 02, 06   pp65361–376 DR11 [24]
  06 11, 16 3*02, 5*02 0301, 05   
  11 0102, 1101 3*0202 0301, 0501 DRB1*11 pp65361–375 DR11 [11]
  14 0402, 1101 3*02, 4*0103 0301, 0302   
pp65489–503 06 11, 16 3*02, 5*02 0301, 05 DRB3*02  
  13 13, 1501 3*02, 5*01 06   pp65489–503
  14 0402, 1101 3*02, 4*0103 0301, 0302   DR11,3 [24]
  17 13,1503 3*02, 5*01 06   pp65505–523 DR52 [11]
pp65505–519 06 11, 16 3*02, 5*02 0301, 05 DQB1*0502 pp65505–523 DR1 [23]
pp65509–523 12 03021, 1503 3*01, 5*01 06 DRB3*0101  
  14 0402, 1101 3*02, 4*0103 0301, 0302 No cells available pp65509–524 DR3 [24]
  1. The HLA antigen restrictions identified are shown in bold