Table 10 Individual pp65 Epitopes that Induced intracellular IFN-γ Production by CD4+ T Cells, the HLA Type of Donors With Reactive CD4+ T Cells, and the HLA Antigen Restriction of Each Epitope
From: CMV pp65 and IE-1 T cell epitopes recognized by healthy subjects
Peptide(s) | Donor | DRB1* | DRB- | DQB1* | HLA Antigen Restriction | Published Antigen Restriction |
|---|---|---|---|---|---|---|
|  | 12 | 03021, 1503 | 3*01, 5*01 | 06 | DRB1*15 or DRB5*01 | pp65225–239 DR15 [23] |
pp65221–235 | 08 | 13031, 1503 | 3*02, 3*02 | 02, 06 |  |  |
| Â | 10 | 0701, 1302 | 3*0301, 4*0401 | 0202, 0604 | No cells available | Â |
pp65285–299 | 07 | 0401, 0701 | 4*01, 4*01 | 0303, 03 | No cells available | pp65281–295 DR4, 7 [11] |
pp65365–379 | 01 | 0901, 11 | 3*00, 4*01 | 02, 06 |  | pp65361–376 DR11 [24] |
| Â | 06 | 11, 16 | 3*02, 5*02 | 0301, 05 | Â | Â |
|  | 11 | 0102, 1101 | 3*0202 | 0301, 0501 | DRB1*11 | pp65361–375 DR11 [11] |
| Â | 14 | 0402, 1101 | 3*02, 4*0103 | 0301, 0302 | Â | Â |
pp65489–503 | 06 | 11, 16 | 3*02, 5*02 | 0301, 05 | DRB3*02 |  |
|  | 13 | 13, 1501 | 3*02, 5*01 | 06 |  | pp65489–503 |
| Â | 14 | 0402, 1101 | 3*02, 4*0103 | 0301, 0302 | Â | DR11,3 [24] |
|  | 17 | 13,1503 | 3*02, 5*01 | 06 |  | pp65505–523 DR52 [11] |
pp65505–519 | 06 | 11, 16 | 3*02, 5*02 | 0301, 05 | DQB1*0502 | pp65505–523 DR1 [23] |
pp65509–523 | 12 | 03021, 1503 | 3*01, 5*01 | 06 | DRB3*0101 |  |
|  | 14 | 0402, 1101 | 3*02, 4*0103 | 0301, 0302 | No cells available | pp65509–524 DR3 [24] |