HLA allele | hTRT peptide | Sequence | In vivo peptide immunization in HLA Tg mice R/T | In vitro immunogenicity in PBMC | Tet | Killing of tumor cells (hTRT+HLA+) | Ref. | ||
---|---|---|---|---|---|---|---|---|---|
 |  |  |  | Normal donors | Cancer patients |  | 51Cr- release assay | IFNγ/ELISPOT |  |
A*0201 | p540 | ILAKFLHWL | 8/10 | 11/12 | 9/13 | + | T2*, LnCap, MCF-7, H69 624, SW480 | ND | [30] |
 |  |  | ND | 5/5 | ND | + | T2*,36 M, U266, IM9, SKW6.4, K029 | ND | [29] |
 |  |  | ND | ND | 5/6 | + | T2*, U266, IM9, K029, SKMEL2 | ND | [66] |
 |  |  | ND | ND | 21/23 | + | T2*, BJAB, LnCap | ND | [67] |
 |  |  | ND | 0/12 | 5/37 | ND | ND | + | [68] |
 |  |  | ND | 4/20 | 11/14 | ND | ND | + | [69] |
 | p865 | RLVDDFLLV | 7/10 | 7/10 | 5/9 | + | T2*, LnCap, MCF-7,624, SW480 | ND | [30] |
 |  |  | ND | 0/12 | 4/37 | ND | ND | + | [68] |
 |  |  | ND | 2/20 | 6/14 | ND | ND | + | [69] |
 | p572 | RLFFYRKSV | ND | 0/3 | 1/4 | ND | T2* | ND | (unpublished data) |
 | pY572 | YLFFYRKSV | 7/7 | 4/6 | 5/8 | + | T2*, U266, HELA-HHD | ND | [49] |
B*0702 | p277 | RPAEEATSL | 4/6 | 7/8 | ND | ND | T2-B7*, T1-B7, JY, Jurkat | ND | [70] |
 |  |  | 5/6 | 5/8 | ND | ND | ND | ND | [70] |
 | p342 | RPSFLLSSL | 2/6 | 2/8 | ND | ND | T2-B7*, T1-B7, JY, Jurkat | ND | [70] |
 |  |  | 4/4 | 5/8 | ND | ND | ND | ND | [70] |
 | p351 | RPSLTGARRL | 5/6 | 6/8 | ND | ND | T2-B7*, T1-B7, JY, Jurkat, LB34, KUL68, U293T | ND | [71] |
 | p444 | DPRRLVQLL | 2/7 | 1/8 | ND | ND | ND | ND | [70] |
 | p464 | FVRACLRRL | 4/4 | 3/8 |  |  |  |  |  |
 | p1107 | LPGTTLTAL | 2/4 | 5/8 |  |  |  |  |  |
 | p1123 | LPSDFKTIL | 7/8 | 10/11 | 2/2 |  | T2-B7*, JY | + |  |
A*0101 | p325 | YAETKHFLY | ND | 1/2 | ND | ND | EVB-DDU*, MOU, AKR | + | [72] |
A*0301 | p973 | KLFGVLRLK | ND | 2/3 | 2/2 | ND | T2-A3*, U266, SKMES1, NHL, SK-MEL-2 | ND | [73] |
 |  |  |  | 2/6 | 4/7 | ND | ND | + | [69] |
A*2401 | p324 | VYAETKHFL | 2/3 (pDNA hTRT) | 2/17 | 9/72 | ND | EBV-PBMC*, KH88, MEG01, OUN1, HepG2, HuH6, HuH7 | + | [74–76] |
 | p461 | VYGFVRACL | 3/3 (pDNA hTRT) | 3/17 | 5/72 | + | EBV-PBMC*, HepG2, HuH6, HuH7 | + |  |
 | p1088 | TYVPLLGSL | 3/3 (pDNA hTRT) | 0/13 | 6/72 | ND |  |  | [74–76] |
 | p845 | CYGDMENKL | 2/3 (pDNA hTRT) | 0/13 | 6/72 | ND |  |  |  |
 | p637 | DYVVGARTF | 2/3 (pDNA hTRT) | 0/11 | 9/72 | ND |  |  | [76] |
 | p167 | AYQVCGPPL | 1/3 (pDNA hTRT) | 0/11 | 9/72 | ND |  |  |  |