Skip to main content

Table 2 Identification, Analysis and Characterization of HLA-restricted Telomerase Peptide

From: Telomerase immunity from bench to bedside: round one

HLA allele

hTRT peptide

Sequence

In vivo peptide immunization in HLA Tg mice R/T

In vitro immunogenicity in PBMC

Tet

Killing of tumor cells (hTRT+HLA+)

Ref.

    

Normal donors

Cancer patients

 

51Cr- release assay

IFNγ/ELISPOT

 

A*0201

p540

ILAKFLHWL

8/10

11/12

9/13

+

T2*, LnCap, MCF-7, H69 624, SW480

ND

[30]

   

ND

5/5

ND

+

T2*,36 M, U266, IM9, SKW6.4, K029

ND

[29]

   

ND

ND

5/6

+

T2*, U266, IM9, K029, SKMEL2

ND

[66]

   

ND

ND

21/23

+

T2*, BJAB, LnCap

ND

[67]

   

ND

0/12

5/37

ND

ND

+

[68]

   

ND

4/20

11/14

ND

ND

+

[69]

 

p865

RLVDDFLLV

7/10

7/10

5/9

+

T2*, LnCap, MCF-7,624, SW480

ND

[30]

   

ND

0/12

4/37

ND

ND

+

[68]

   

ND

2/20

6/14

ND

ND

+

[69]

 

p572

RLFFYRKSV

ND

0/3

1/4

ND

T2*

ND

(unpublished data)

 

pY572

YLFFYRKSV

7/7

4/6

5/8

+

T2*, U266, HELA-HHD

ND

[49]

B*0702

p277

RPAEEATSL

4/6

7/8

ND

ND

T2-B7*, T1-B7, JY, Jurkat

ND

[70]

   

5/6

5/8

ND

ND

ND

ND

[70]

 

p342

RPSFLLSSL

2/6

2/8

ND

ND

T2-B7*, T1-B7, JY, Jurkat

ND

[70]

   

4/4

5/8

ND

ND

ND

ND

[70]

 

p351

RPSLTGARRL

5/6

6/8

ND

ND

T2-B7*, T1-B7, JY, Jurkat, LB34, KUL68, U293T

ND

[71]

 

p444

DPRRLVQLL

2/7

1/8

ND

ND

ND

ND

[70]

 

p464

FVRACLRRL

4/4

3/8

     
 

p1107

LPGTTLTAL

2/4

5/8

     
 

p1123

LPSDFKTIL

7/8

10/11

2/2

 

T2-B7*, JY

+

 

A*0101

p325

YAETKHFLY

ND

1/2

ND

ND

EVB-DDU*, MOU, AKR

+

[72]

A*0301

p973

KLFGVLRLK

ND

2/3

2/2

ND

T2-A3*, U266, SKMES1, NHL, SK-MEL-2

ND

[73]

    

2/6

4/7

ND

ND

+

[69]

A*2401

p324

VYAETKHFL

2/3 (pDNA hTRT)

2/17

9/72

ND

EBV-PBMC*, KH88, MEG01, OUN1, HepG2, HuH6, HuH7

+

[74–76]

 

p461

VYGFVRACL

3/3 (pDNA hTRT)

3/17

5/72

+

EBV-PBMC*, HepG2, HuH6, HuH7

+

 
 

p1088

TYVPLLGSL

3/3 (pDNA hTRT)

0/13

6/72

ND

  

[74–76]

 

p845

CYGDMENKL

2/3 (pDNA hTRT)

0/13

6/72

ND

   
 

p637

DYVVGARTF

2/3 (pDNA hTRT)

0/11

9/72

ND

  

[76]

 

p167

AYQVCGPPL

1/3 (pDNA hTRT)

0/11

9/72

ND

   
  1. R/T: responders/total, Tet: Tetramer staining, ND: Not Done
  2. *, denotes target cells pulsed with corresponding peptide