Table 2 Differentially expressed genes between relative normal and dystrophic muscles from the same AR-LGMD patient
Accession no. | Gene title (gene symbol) | Gene expression pattern in dystrophic muscle |
|---|---|---|
Muscle development and function | ||
NM_133437 | Titin (TTN), transcript variant novex-2 | Down |
NM_002470 | Myosin, heavy polypeptide 3, skeletal muscle, embryonic (MYH3) | Down |
NM_000257 | Myosin, heavy polypeptide 7, cardiac muscle, beta (MYH7) | Down |
NM_000432 | Myosin, light polypeptide 2, regulatory, cardiac, slow (MYL2) | Down |
NM_194293 | Cardiomyopathy associated 1 (CMYA1) | Down |
NM_004543 | Nebulin | Down |
NM_006175 | Nebulin-related anchoring protein (NRAP), transcript variant 1 | Down |
Ion homeostasis | ||
NM_003374 | Voltage-dependent anion channel 1 | Down |
Energy metabolism | ||
NM_002612 | Pyruvate dehydrogenase kinase, isoenzyme 4 (PDK4) | Down |
NC_001807 | NADH dehydrogenase subunit 2 | Down |
NM_013402 | Fatty acid desaturase 1 (FADS1) | Up |
Signal transduction and regulator | ||
NM_182926 | Kinectin 1 (Kinesin receptor) | Up |
NM_002901 | Reticulocalbin1, EF hand calcium binding domain | Up |
NM_014365 | Heat shock 22 kDa protein 8 (HSPB8) | Down |
NM_206876 | Protein phosphatase 1, catalytic subunit, beta isoform | Down |
NM_030937 | Cyclin L2 (CCNL2) | Down |
NM_014001 | ADP-ribosylation factor binding protein GGA3 | Down |
NM_003566 | Early endosome antigen 1 | Up |
NM_030571 | Nedd4 family interacting protein 1 (NDFIP1) | Up |
NM_000599 | Insulin-like growth factor binding protein 5 (IGFBP5) | Up |
NM_003916 | Adaptor-related protein complex 1, sigma 2 subunit | Down |
Regulator for gene expression and protein translation | ||
NM_139045 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2), transcript variant 2 | Up |
NM_012433 | Splicing factor 3b, subunit 1, 155 kDa (SF3B1) | Up |
NM_014752 | Signal peptidase complex subunit 2 homolog (S. cerevisiae) (SPCS2), mRNA | Down |
NM_001006 | Ribosomal protein S3A (RPS3A) | Down |
Others | ||
NM_020384 | CLDN2 gene for claudin 2 | Down |
NM_016056 | Transmembrane BAX inhibitor motif containing 4 | Down |
AF168681 | CRIM1 protein gene, partial cds; and FEZ2 gene | Up |
NM_001017977 | IQ motif and WD repeats 1 (IQWD1), transcript variant 2 | Down |
BK001418 | Metastasis associated in lung adenocarcinoma transcript 1 long isoform, transcribed non-coding RNA | Up |
AF268386 | DPDP-3 dental pulp-derived protein 3 | Down |
Unknown genes | ||
DW009597 | 3A-B | Down |
EC268059 | 5A-C | Up |
EC268060 | 24A-A | Down |
EC268061 | 5A-D | Down |
EC268062 | 7B-B | Down |
EC268063 | 2A-A | Down |
EC268064 | 18B-C | Up |
EC268065 | 29B-A | Up |
EC268066 | 25A-A | Down |
EC268067 | 23A-C | Down |
EC268068 | 29A-C | Down |
EC268069 | A1 | Up |