Physical and clinical examination | Clinical symptoms or indications |
---|---|
Physical development | Normal |
Psychological development | Normal |
Age onset | Two sisters in the second decade, the oldest in the third decade |
First symptoms | Difficulty in climbing stairs and standing up from chair |
Pattern of muscle involvement | Lower and upper limb-girdle muscle |
Clinical course | Slow |
Pseudohypertrophy of calf | Transient calf hypertrophy at early stage |
cardiomyopathy | No |
Serum creatine kinase (SCK) | Very high, approximately 10 times than normal |
EMG | Myopathic damage |
Muscle biopsy | Typical muscle dystrophic change |