Table 2 Established anti-tumor activities of IL-1 blocking methods and/or therapies based on published literature.
Study | Year | Observation |
|---|---|---|
Voronov et al [7] | 2003 | IL-1 KO mice failed to develop solid tumors post injection of melanoma cells and exhibited significantly improved survival compared with wild type animals. |
Saijo et al [19] | 2002 | Overexpression of IL-1 is associated with an aggressive/malignant phenotype. |
Sawai et al [22] | 2003 | Same observation as above |
Voronov et al [7] | 2003 | Same observation as above |
Weinreich et al [28] | 2003 | IL-1ra-transduced xenografts exhibited decreased tumor growth and metastases in murine models. |
Elaraj et al [15] | 2006 | Exogenously administered IL-1ra (anakinra) decreased tumor proliferation rate, metastases, and IL-8 and VEGF mRNA expression of xenografts in murine models. |