Characterization of highly frequent epitope-specific CD45RA+/CCR7+/- T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+ BKV-seropositive donors

Table 3 Selected sequences as they nest in the LTag domains

p300 domain 1–82	MDKVLNREESMELMDLLGLERAAWGNLSLMRKAYLRKCKEFHPDKGGDEDKMKRMNTLYKKMEQDVK
pRb domain 101–118	VAHQPDFGTWSSSEVPTYGTEEWESWWSSFNEKWDEDLFCHEDMFASDEEATADSQHSTPPKKKR
	KVEDPKDFPCDLHQFLSQAVFSNRTLACFAVYT TKEKAQILYKKLMEKYSVT FISRHMCAGHNIIF
DNA binding	FLTPHRHRV SAINNFCQKLCTFSFLI CKGVNKEYLLYSALTRDPYHTIEESIQGGLKEHDFNPEEPEETKQVSW
	KLITEYAVETKCEDVFLLLGMYLEFQYNVEECKKCQKKDQPYHFKYHEKHFANATIFAESKNQKSICQQAVDTVLAKK
p53 domain 351–450	RVDSLHMTREEMLTERFNHI LDKMDLIFGAHGNAVLEQYMAGVAWLHCLLPKMDSVIFDFLHCIVFNV
	PKRRYWLFKGPIDSGKTTLAAGLLDL CGGKAL
ATPase activity	NVNLPMERLTFELGVAIDQYMVVFEDVKGT GAESKDLPSGHGINNLDSLRDYLDGSVKVNLEKKHLNKRTQIFPP
	GLVTMNE
p53 domain 533–626	YPVPKTLQARFVRQIDFRPKIYLRKSLQNSEFLL EKRILQSGMTLLLLLIWFRPV ADFATDIQSRIVEWKERLD
	SEISMYTFSRMKYNICMGKC
	ILDITREEDSETEDSGHGSSTESQSQCSSQVSDTSAPAEDSQRSDPHSQELHLCKGFQCFKRPKTPPPK

ISSN: 1479-5876