From: Gene expression in acute Stanford type A dissection: a comparative microarray study
Gene Name | Platform | Atlas | Affymetrix | regulation | ||
---|---|---|---|---|---|---|
Functional group | Array type | ratio D/C | P value | ratio D/C | P value | |
extracellular matrix proteins, | ||||||
cell surface antigens, adhesion proteins | ||||||
collagen IV α2, COL4A2 | h | 0.5 | <0.01 | 0.4 | <0.05 | ↓ |
collagen IV α5, COL4A5 | n.t. | 0.32 | <0.05 | ↓ | ||
collagen VI α3, COL6A3 | c | 1.9 | <0.05 | n.s. | ? | |
collagen VIII α1, COL8A1 | c | 0.3 | <0.01 | 0.3 | <0.001 | ↓ |
collagen VIII α2, COL8A2 | n.t. | 0,4 | <0,01 | ↓ | ||
collagen XIV α1, COL14A1, undulin | c | 0.4 | <0.001 | 0.5 | <0.001 | ↓ |
collagen XVIII α1, COL18A1 | n.t. | 0.47 | <0.001 | ↓ | ||
polycystin1, PKD1 | h | 0.3 | <0.001 | 0.4 | <0.01 | ↓ |
polycystin 2, PKD2 | n.t. | 0.4 | <0.001 | ↓ | ||
clusterin, SP-40; | h | 0.5 | <0.01 | 0.5 | <0.01 | ↓ |
integrin α7B, IGA7B | h | 0.4 | <0.001 | 0.3 | <0.001 | ↓ |
gap junction protein, connexin 43 | c | 0.6 | <0.05 | n.s. | ? | |
SPARC-like 1 | c | 0.3 | <0.001 | 0.6 | <0.001 | ↓ |
decorin | c | 0.3 | <0.05 | n.s. | ↓ | |
elastin | n.t. | 0.4 | <0.05 | ↓ | ||
fibulin 5 | n.t. | 0.4 | <0.001 | ↓ | ||
cell surface glycoprotein MUC18 | h | 0.3 | <0.001 | 0.5 | <0.01 | ↓ |
fibronectin receptor | h | n.s. | 3.4 | <0.01 | ↑ | |
ras homolog gene family member B | h | 0.5 | <0.05 | n.s. | ? | |
extracellular matrix proteolysis | ||||||
MMP-11 | h | 2.1 | <0.001 | 3.2 | <0.05 | ↑ |
MMP-14 | n.t. | 2.5 | <0.01 | ↑ | ||
MMP-19 | n.t. | 3.2 | <0.05 | ↑ | ||
TIMP1 | h,c | 1.8 | <0.01 | n.s. | ? | |
TIMP2 | h,c | 0.4 | <0.01 | n.s. | ? | |
TIMP3 | c | 0.2 | <0.001 | n.s. | ? | |
cell motility and cytoskeleton proteins | ||||||
vinculin | c | 0.2 | <0.001 | n.s. | ? | |
actinin α1 | c | 0.5 | <0.001 | 0.8 | <0.01 | ↓ |
filamin A | c | 0.3 | <0.001 | 0.5 | <0.001 | ↓ |
actin α2 | n.t. | 0.13 | <0.001 | ↓ | ||
actinin α4 | n.t. | 0.44 | <0.001 | ↓ | ||
gelsolin | n.t. | 0.5 | <0.01 | ↓ | ||
leiomodin | n.t. | 0.4 | <0.01 | ↓ | ||
tropomyosin 1 | n.t. | 0.4 | <0.01 | ↓ | ||
calponin | n.t. | 0.3 | <0.001 | ↓ | ||
smooth & non-muscle myosin light chain kinase | h | 0.4 | <0.001 | n.t. | ↓ | |
smooth muscle myosin heavy chain, SM2 | n.t. | 0.5 | <0.001 | ↓ | ||
myosin regulatory light chain2, smooth muscle | n.t. | 0.5 | <0.001 | ↓ | ||
metabolism | n.t. | |||||
low-density lipoprotein receptor, LDLR | c | 0.4 | <0.001 | 1.6 | <0.01 | ? |
Kunitz-type serine protease inhibitor 2, SPINT2 | h | 0.2 | <0.001 | 0.3 | <0.001 | ↓ |
aldehyde dehydrogenase 2, mitochondrial | c | 0.3 | <0.01 | 0.6 | <0.01 | ↓ |
diaphorase (NADH), cytochrome b-5 reductase | c | 0.5 | <0.01 | n.s. | ? | |
superoxide dismutase 3, extracellular | c | 0.4 | <0.01 | 0.4 | <0.001 | ↓ |
lipase A | c | 2.6 | <0.05 | n.s. | ? | |
protease inhibit, PI1, alpha-1-antitrypsin | h | 5.5 | <0.001 | ↑ | ||
GABA-B receptor 1A subunit | h | 1.8 | <0.001 | n.e. | ? | |
prostaglandin I2 prostacyclin synthetase | c | 0.4 | <0.05 | 0.81 | <0,001 | ↓ |
Gene Name | Platform | Atlas | Affymetrix | regulation | ||
Functional group | Array type | ratio D/C | P value | ratio D/C | P value | ratio D/C |
Protein turnover | ||||||
purine-rich element-binding protein A | h | 0.4 | <0.01 | 0.6 | <0.05 | ↓ |
glutathione S-transferase theta 1 | h | 0.4 | <0.01 | 0.2 | <0.05 | ↓ |
58-kDa inhibit. of RNA-activated protein kinase | h | 0.3 | <0.01 | ↓ | ||
G1/S-specific cyclin D1 | h | 0.5 | <0.01 | n.s. | - | |
carboxypeptidase H, CPE; enkephalin convertase | h | 0.4 | <0.01 | ↓ | ||
ribos. protein S6 kinase II α1, S6KII-alpha 1 | h | 3.1 | <0.001 | n.s. | - | |
carboxypeptidase N, polypeptide 1, 50 kD | c | 2.0 | <0.05 | n.e. | - | |
eukariotic translation initiantion factor 4E bind prot 1 | n.t. | 2.9 | <0.01 | ↑ | ||
60 S acdic ribosomal protein PO | n.t. | 3.0 | <0.01 | ↑ | ||
FOS-related antigen 1 | h,c | 4.9 | <0.01 | 3.6 | <0.05 | ↑ |
myc proto-oncogene | h | 3.5 | <0.01 | 2.8 | <0.05 | ↑ |
ets domain protein elk-3; NET; SRF accessory protein | h | 2.1 | <0.001 | 4.4 | <0.05 | ↑ |
adenine phosphoribosyltransferase | n.t. | 2.1 | <0.001 | ↑ | ||
high mobility group prot isoforms I & Y, HMGIY | h | 10.1 | <0.001 | 6,0 | <0.01 | ↑ |
superoxide dismutase 2, mitochondrial | c | 2.6 | <0.01 | 3.7 | <0.001 | ↑ |
Cell receptors | ||||||
Natriuretic peptide receptor A/guanylate cyclase A | c | 0.4 | <0.001 | 0.3 | <0.001 | ↓ |
natriuretic peptide receptor C/guanylate cyclase C | c | 0.5 | <0.001 | n.s. | - | |
protein tyrosine phosphatase receptor type F | c,h | 0.4 | <0.01 | n.t. | - | |
growth factors | ||||||
vascular endothelial growth factor, VEGF | h | 4.7 | <0.05 | n.s. | - | |
endothelin 2 | c | 0.6 | <0.01 | n.e. | - | |
fibroblast growth factor receptor1 | h | 0.6 | <0.01 | 0.7 | <0.05 | ↓ |
insulin-like growth factor-binding protein 2, IGFBP2 | h | 0.3 | <0.001 | 0.2 | <0.01 | ↓ |
cardiotrophin 1 | c | 0.4 | <0.001 | 0.5 | >0.05 | ↓ |
pleiotrophin, heparin-binding growth factor 8, HBGF8 | h | 0.5 | <0.05 | 0.6 | <0.05 | ↓ |
inflammation + stress response | ||||||
colony-stimulating factor 1 receptor, CSF1R | h | 2.0 | <0.05 | 1.7 | <0.05 | ↑ |
myeloid cell nuclear differentiation antigen | h | 3.5 | <0.001 | 3.9 | <0.05 | ↑ |
tumor necrosis fact recept superfam memb 1B | h | 2.0 | <0.001 | n.s. | - | |
granulocyte colony stimul factor recept | h | 3.5 | <0.01 | n.e. | - | |
interleukin 2 receptor alpha subunit, IL-2, CD25 antigen | h | 3.1 | <0.001 | 5.3 | <0.001 | ↑ |
interleukin 6, IL-6 | h | 3.9 | <0.01 | 4.3 | <0.001 | ↑ |
interleukin 8, IL-8 | 12.2 | <0.05 | ↑ | |||
small inducible cytokine subfamily A member 2 | h,c | 3.8 | <0.01 | 2.2 | <0.05 | ↑ |
90-kDa heat-shock proteinA HSP90A | h | 2.6 | <0.05 | n.t. | ↑ | |
60-kDa heat shock protein HSP60 | h | 2.7 | <0.05 | n.t. | ↑ | |
CD9 antigen p24 | c | 0.5 | <0.001 | 0.5 | <0.01 | ↓ |
27-kDa heat shock protein HSP27 | h | 0.4 | <0.001 | n.t. | - | |
blood, hemostasis | ||||||
endothelial plasminogen activator inhibit 1, PAI1 | h | 2.8 | <0.05 | 4.0 | <0.05 | ↑ |
thrombomodulin | h | 2.8 | <0.05 | n.s. | - | |
hexabrachion, tenascin C | c | 2.6 | <0.01 | 6.2 | <0.05 | ↑ |
heme oxygenase 1 | h | 15.4 | <0.05 | 3.6 | <0.05 | ↑ |
tissue factor pathway inhibit, coagulation inhibit | c | 2.0 | <0.05 | 1.6 | <0.05 | ↑ |
tissue factor pathway inhibitor 2 | c | 2.3 | <0.05 | 3.0 | <0.05 | ↑ |
others | ||||||
c-fgr proto-oncogene p55-FGR | h | 2.6 | <0.01 | 2.6 | <0.01 | ↑ |
erbB3 proto-oncogene; HER3 | h | 3.7 | <0.001 | n.t. | ↑ | |
caspase 4 | h | 1.9 | <0.05 | n.t. | ↑ | |
follistatin-related protein | h | 0.5 | <0.01 | 0.6 | <0.01 | ↓ |
Gem; induced immediate early protein | h | 0.2 | <0.001 | 0.3 | <0.001 | ↓ |
parathymosin athymosin | h | 0.6 | <0.05 | 0.8 | n.s. | - |
prostaglandin I2 (prostacyclin) synthase | c | 0.4 | <0.05 | n.t. | <0.001 | ↓ |
calcium-activated potassium channel beta subunit | h | 0.3 | <0.001 | 0.4 | <0.01 | ↓ |
solute carrier fam 4 anion exchanger member 3 | c | 0.5 | <0.001 | n.t. | - |