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Table 1

From: Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets

Ethnic Group Class Comparison Student t test
p2-value < 0.005
# genes differentially expressed
Permutation Test (p-value)
Multivariate Univariate
a) All Donors (n = 47) IL-2 vs No-Stim 1690 0 0.007
b) Chinese (n = 17) IL-2 vs No-Stim 411 0.001 0.019
c) Caucasians (n = 30) IL-2 vs No-Stim 1340 0 0.009
d) Caucasians (n = 17) IL-2 vs No-Stim 784 0 0.01
Ethnic Group Class Comparison Student t test
p 2 -value < 0.05
# genes differentially expressed
Permutation Test (p-value)
    Multivariate Univariate
e) All Donors (n = 47) IL-2 vs No-Stim 3926 0 0
  1. Genes with expression altered by exposure of PBMC in response to rIL-2 (300 IU/ml) in vitro – BMC were obtained from 30 Caucasian (Ca) and 17 Chinese (Ch) normal donors. Class comparison was performed by two-tailed Student t test with as cutoff of significance a p2-value <0.005 comparing CY5/Cy3 log2 ratios between test and reference samples (see Materials and Methods). Multivariate and univariate permutation test evaluated the significance of the comparisons.