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Figure 6 | Journal of Translational Medicine

Figure 6

From: Combined IL-21 and Low-Dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor model

Figure 6

Quantitation of absolute numbers of Tem and Tcm CD8+ T cells. PBMCs were examined by flow cytometry to determine the absolute number of Tem (CD62L-/CD127+) pmel CD8+ T cells (A), and Tcm (CD62L+/CD127+) pmel CD8+ T cells (B) on days 14, 21, and 28 after vaccination and cytokine treatment. IL-21 + IL-2 supported the highest level of circulating Tem cells on all three days compared to all other experimental groups (p = 0.011), and stimulated the greatest increase of Tcm cells on days 21 and 28 (p = 0.029). Data was collected from pooled blood from ≥ 5 mice in each test group.

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Journal of Translational Medicine

ISSN: 1479-5876

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