Table 4 Plasma levels of cytokines and growth factors before and during 3 months of treatment.
Cytokine or Chemokine | Day* | No. of Patients | Mean Concentration (pg/mL) | Change from Day -8 (pg/mL) | P value† |
|---|---|---|---|---|---|
IL-1α | -8 | 13 | 43 | ||
-4 | 12 | 47 | 5.2 | 0.224 | |
1 | 13 | 48 | 4.8 | 0.172 | |
9 | 13 | 48 | 4.6 | 0.437 | |
3M | 11 | 29 | -16.3 | 0.033 | |
IL-1β | -8 | 13 | 109 | ||
-4 | 12 | 115 | 8.0 | 0.295 | |
1 | 13 | 122 | 13.6 | 0.052 | |
9 | 13 | 125 | 16.4 | 0.069 | |
3M | 11 | 106 | - 6.4 | 0.501 | |
IL-6 | -8 | 13 | 62 | ||
-4 | 12 | 76 | 12.3 | 0.166 | |
1 | 13 | 72 | 10.2 | 0.164 | |
9 | 13 | 79 | 16.3 | 0.094 | |
3M | 11 | 50 | -18.4 | 0.014 | |
IL-8 | -8 | 13 | 12 | ||
-4 | 12 | 15 | 3.0 | 0.074 | |
1 | 13 | 14 | 1.9 | 0.222 | |
9 | 13 | 13 | 1.2 | 0.463 | |
3M | 11 | 8 | - 4.6 | 0.019 | |
IL-10 | -8 | 13 | 9 | ||
-4 | 12 | 14 | 4.1 | 0.130 | |
1 | 13 | 11 | 1.7 | 0.149 | |
9 | 13 | 12 | 3.4 | 0.157 | |
3M | 11 | 9 | - 1.2 | 0.418 | |
TNF-α | -8 | 13 | 150 | ||
-4 | 12 | 177 | 26.8 | 0.265 | |
1 | 13 | 174 | 23.4 | 0.200 | |
9 | 13 | 152 | 1.6 | 0.937 | |
3M | 11 | 121 | -39.8 | 0.377 | |
GM-CSF | -8 | 13 | 2.9 | ||
-4 | 11 | 7.1 | 4.1 | 0.007 | |
1 | 13 | 3.5 | 0.6 | 0.012 | |
9 | 13 | 11.6 | 8.6 | 0.005 | |
3M | 11 | 5.7 | 2.6 | 0.041 | |
M-CSF | -8 | 13 | 519 | ||
-4 | 12 | 505 | -26.0 | 0.847 | |
1 | 13 | 610 | 90.8 | 0.153 | |
9 | 13 | 863 | 343.9 | 0.007 | |
3M | 11 | 558 | 13.6 | 0.902 |