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Figure 5 | Journal of Translational Medicine

Figure 5

From: In vitro and in vivo evaluation of NCX 4040 cytotoxic activity in human colon cancer cell lines

Figure 5

(A) COX-1 and COX-2 basal mRNA and protein expression in the different cell lines. Lane a, LoVo cells; lane b, WiDr cells; lane c, LRWZ cells; lane d, LoVo Dx. (B) COX-1 protein expression in the different cell lines. LoVo: lane 1, untreated cells; lane 2, cells exposed to 10 μM of NCX 4040 (24 h); LoVo Dx: lane 3, untreated cells; lane 4, cells exposed to 50 μM of NCX 4040 (24 h); WiDr: lane 5, untreated cells; lane 6, cells exposed to 50 μM of NCX 4040 (24 h); LRWZ: lane 7, untreated cells; lane 8, cells exposed to 50 μM of NCX 4040 (24 h). (C) COX-2 protein expression in WiDr and LoVo Dx cell lines after different exposure schemes to 10 μM of NCX 4040. Lane 1, untreated cells (24 h); lane 2, NCX 4040 (24 h); lane 3, untreated cells (24 h) + washout (24 h); lane 4, NCX 4040 (24 h) + washout (24 h).

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