Table 2 Functional categories of genes differentially upregulated in HIV-VLPs-induced MDDCs. (+) 1.5-fold upregulation; (++) 2–5-fold upregulation; (+++) >5-fold upregulation.
Pathway | HIV-VLP vs PBS | HIV-VLP vs LPS | Pathway | HIV-VLP vs PBS | HIV-VLP vs LPS |
|---|---|---|---|---|---|
Cell cycle, death | Chemokine/Immunology | ||||
TNF | ++ | + | Innate response | Â | Â |
BIRC3 | ++ | Â | IL8 | +++ | ++ |
CASP7 | + | Â | CXCL1 | ++ | ++ |
BID | ++ | Â | IL1a | ++ | ++ |
PAK2 | ++ | Â | IL1b | ++ | Â |
TRAF2 | ++ | Â | IL6 | ++ | Â |
BCL2L1 | + | Â | CCL4 | ++ | Â |
IGF1R | ++ | Â | IFNG | Â | + |
TNFAIP3 | ++ | Â | PTGER4 | Â | Â |
TANK | ++ | Â | Adaptive response | Â | Â |
PSEN1 | + | Â | EBI2 | ++ | Â |
TNFRSF1B | +++ | + | ICAM1 | ++ | Â |
Transcription | Â | Â | B2M | + | Â |
NFKB1 | + | Â | Receptors | Â | Â |
NFKBIA | Â | ++ | IL15RA | ++ | Â |
IRAK1 | + | Â | IL18R1 | ++ | Â |
MAP3K1 | Â | + | IL23A | ++ | Â |
JUNB | + | Â | IL2RB | ++ | Â |
Signaling | Â | Â | FCGR2A | ++ | Â |
MAP2K7IP2 | + | Â | IL7R | ++ | Â |
DUSP1 | ++ | + | CD83 | ++ | Â |
MAP2K3 | + | Â | Growth Factors | Â | Â |
PAK2 | ++ | Â | CSF1 | ++ | Â |
RB1 | Â | + | CSF2 | + | Â |
FOXO3A | + | Â | Migration and Homeostasis | Â | Â |
FYN | Â | + | CCR7 | + | Â |
GNAQ | + | Â | FPR1 | ++ | Â |
MEF2A | + | Â | SELE | ++ | Â |
RAPGEF2 | Â | + | CD44 | ++ | Â |
| Â | Â | Â | LTBR | + | Â |
| Â | Â | Â | T-cell activation/polarization | Â | Â |
| Â | Â | Â | CD40 | ++ | Â |
| Â | Â | Â | TNFSF9 | Â | + |
| Â | Â | Â | IL18 | + | Â |