Table 1 Pathways involved in the HIV-VLPs-activated MDDCs. The pathways are derived from the BioCarta through the Cancer Genome Anatomy Project at http://cgap.nci.nih.gov/Pathways/BioCarta_Pathways. Genes with at least a 2-fold modulation (up or downregulation) have been taken into consideration. Upregulated genes in bold and underline; Downregulated genes in plain text.
Pathways | HIV-VLP vs PBS | HIV-VLP vs LPS | Pathways | HIV-VLP vs PBS | HIV-VLP vs LPS | Pathways | HIV-VLP vs PBS | HIV-VLP vs LPS |
|---|---|---|---|---|---|---|---|---|
Cell cycle, death | Transcription | Immunology/Signaling | ||||||
Cadmium induces DNA synthesis and proliferation in macrophages | NFKB1 MAPK1 | TNF | Acetylation and Deacetylation of RelA in The Nucleus | NFKB1 FADD | NFKBIA TNF FADD | AKT Signaling Pathway | FOXO3A NFKB1 CASP9 YWHAH | Â |
Caspase Cascade in Apoptosis | BIRC3 CASP7 CASP2 CASP9 PARP1 | Â | Activation of PKC through G protein coupled receptor | GNAQ NFKB1 | Â | B Lymphocyte Cell Surface Molecules | CD40 FCGR2A ICAM1 LTBR ITGAL PTPRC | NFKBIA |
Free Radical Induced Apoptosis | GSR IL8 NFKB1 | Â | Chaperones modulate interferon Signaling Pathway | DNAJA3 IFNG NFKB1 | IFNG LIN7A NFKBIA RB1 TNF | CD40L Signaling Pathway | CD40 DUSP1 TNFAIP3 TRAF6 IKBKB | DUSP1 MAP3K1 NFKBIA TNFAIP3 |
Induction of apoptosis through DR3 and DR4/5 Death Receptors | BID CASP10 CASP7 TRAF2 CASP9 FADD | Â | Double Stranded RNA Induced Gene Expression | NFKB1 | Â | CTL mediated immune response against target cells | ICAM1 B2M LTBR ITGAL | Â |
Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells | GNAQ NFKB1 PRKAR1B CAMK1 | Â | Human Cytomegalovirus and Map Kinase Pathways | MAP2K3 NFKB1 MAP2K6 MAPK1 | Â | fMLP induced chemokine gene expression in HMC-1 cells | FPR1 MAP2K2 NFKB1 CAMK1 MAP2K6 MAPK1 | Â |
Regulation of BAD phosphorylation | BCL2L1 IGF1R PRKAR1B MAPK1 RPS6KA1 YWHAH | Â | NFkB activation by Nontypeable Hemophilus influenzae | DUSP1 EP300 MAP2K3 NFKB1 NR3C1 SMAD4 MAP2K6 SMAD3 TGFBR2 | DUSP1 IL8 NFKBIA SMAD4 TNF IKBKB MAP2K6 SMAD3 | Monocyte and its Surface Molecules | ICAM1 ICAM2 CD44 LTBR SELE CD83 HLA-DOA ITGAL PECAM1 | Â |
Role of Mitochondria in Apoptotic Signaling | BCL2L1 BID BIRC3 CASP7 ENDOG CASP9 PDCD8 | Â | NF-kB Signaling Pathway | IRAK1 NFKB1 TNFAIP3 TRAF6 FADD | IL1A MAP3K1 NFKBIA TNF TNFAIP3 FADD | T Cytotoxic Cell Surface Molecules | CD8A ICAM1 LTBR CD2 ITGAL PTPRC | Â |
SODD/TNFR1 Signaling Pathway | BIRC3 TRAF2 FADD | Â | Signal transduction through IL1R | IL1B MAP2K3 NFKB1 TRAF6 IL1RAP MAP2K6 | IL1A MAP3K1 NFKBIA TNF IL1RAP MAP2K6 | T Helper Cell Surface Molecules | ICAM1 LTBR CD2 CD4 ITGAL PTPRC | Â |
Stress Induction of HSP Regulation | CASP9 MAPKAPK3 | IL1A TNF CASP9 CYC1 | TNFR1 Signaling Pathway | PAK2 TRAF2 CASP2 FADD PARP1 | Â | The 4-1BB-dependent immune response | IFNG NFKB1 TNFSF9 TRAF2 | Â |
TNF/Stress Related Signaling | MAP2K3 NFKB1 TANK TRAF2 CASP2 MAP2K6 | Â | TNFR2 Signaling Pathway | DUSP1 NFKB1 TANK TNFAIP3 TRAF2 | DUSP1 MAP3K1 NFKBIA TANK TNFAIP3 TNFRSF1B | Toll-Like Receptor Pathway | IRAK1 MAP2K3 MAP3K7IP2 NFKB1 TRAF6 MAP2K | Â |
Pathways | HIV-VLP vs PBS | HIV-VLP vs LPS | Pathways | HIV-VLP vs PBS | HIV-VLP vs LPS | Â | Â | Â |
Cytokine Network | Phagocytosis | Â | Â | Â | ||||
Cells and Molecules involved in local acute inflammatory response | ICAM1 IL8 LTBR CERKL ITGAL | Â | Instracellular protein transport | APG9L1 RERE RNF4 | Â | Â | Â | Â |
Cytokine Network | IFNG IL18 IL8 | Â | Cytoskeleton | Â | Â | Â | Â | Â |
Cytokines and Inflammatory Response | CSF1 CSF2 IFNG IL7 IL8 IL15 IL15RA IL23 PTGS2 CD4 | Â | Cellular motiliyshape | ARHGEF2 ARPC2 C14orf43 FLJ39378 MARCKS PDE4B PDE5A PLEK PPP1R15A PPP1R15B SLC11A2 SLC1A3 SLC20A1 SLC43A3 | Â | Â | Â | Â |
IL 17 Signaling Pathway | CD8A IL8 CD58 CD2 CD4 | Â | Â | Â | Â | Â | Â | Â |
Th1/Th2 Differentiation | IL18 IL18R | Â | Â | Â | Â | Â | Â | Â |