Figure 3
Isobologram analyses of inhibition of melanoma cell proliferation. A, VMM39 melanoma cells, B, VMM5A melanoma cells, and C, VMM18 melanoma cells. The straight line connecting the IC70 points (additivity line) is the locus of all dose pairs that should give the same effect. A dose pair (data point) below the line is synergistic, a dose pair on the line is additive, and a dose pair above the line is antagonistic. Note: all graphs are on a log-scale.