Figure 5From: Interleukin-1β induced vascular permeability is dependent on induction of endothelial Tissue Factor (TF) activitySchematic of proposed mechanism of IL-1 induced vascular permeability. Local IL-1 production results in tissue factor upregulation on EC's. In the presence of extrinsic clotting cascade factors local thrombin production activates the EC thrombin receptor and results in VE-cadherin disassembly and contraction of cellular F-actin elements. The resulting intercellular gap formation allows efflux of plasma, proteins, and inflammatory cells into the interstitium.Back to article page