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Figure 5 | Journal of Translational Medicine

Figure 5

From: Interleukin-1β induced vascular permeability is dependent on induction of endothelial Tissue Factor (TF) activity

Figure 5

Schematic of proposed mechanism of IL-1 induced vascular permeability. Local IL-1 production results in tissue factor upregulation on EC's. In the presence of extrinsic clotting cascade factors local thrombin production activates the EC thrombin receptor and results in VE-cadherin disassembly and contraction of cellular F-actin elements. The resulting intercellular gap formation allows efflux of plasma, proteins, and inflammatory cells into the interstitium.

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