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Table 2 Antigenic peptide in bone and soft tissue sarcoma

From: A quest for therapeutic antigens in bone and soft tissue sarcoma

Tumor

Antigen

HLA allele

Peptide sequence*

Reference

Synovial sarcoma

SYT-SSX (SSX1,2,4)

A24

PYGYDQ/IMPK

38

  

A24

GYDQ/IMPKK

38,61

  

A24

GYDQ/IMPKI

40

  

B7

QRPYGYDQ/IM

48

Ewing sarcoma

EWS-FLI1 (type 1)

A3, A31, B44

SSSYGQQN/PSYDSVRRGA

49

 

EWS-FLI1 (type 2)

A2, A3, A24, B7, B44, B62

SSSYGQ/QSSLLAYNT

49

Alveolar rhabdomyosarcoma

PAX3-FKHR

A33, A68, B7

TIGNGLSPQ/NSIRHNLSL

49

Osteosarcoma

Papillomavirus binding factor

B55

CTACRWKKACQR

17

  1. Peptide sequences shown to induce cytotoxic T lymphocites or those used in clinical trials are listed. Slash indicates the breakpoint.