Table 5 Procoagulant effects of inflammation products
From: Ovarian cancer, the coagulation pathway, and inflammation
Product | Procoagulant effect |
|---|---|
Leukocytes or MAs | Activate platelets Induce microvascular occlusion Release neutrophil elastase Induce thrombomodulin release from the endothelium Inactivate antithrombin |
Complements | Increase procoagulant factors production Provide membrane surfaces Augment TF expression |
Inflammatory Cytokines | Increase TF production Decrease thrombin, EPCR, and protein S levels Increase C-reactive protein production Increase complement activation Increase platelet count and reactivity |
Chemokines | Activate platelet aggregation and adhesion Attract more leukocytes |