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Table 5 Procoagulant effects of inflammation products

From: Ovarian cancer, the coagulation pathway, and inflammation

Product Procoagulant effect
Leukocytes or MAs Activate platelets
Induce microvascular occlusion
Release neutrophil elastase
Induce thrombomodulin release from the endothelium
Inactivate antithrombin
Complements Increase procoagulant factors production
Provide membrane surfaces
Augment TF expression
Inflammatory Cytokines Increase TF production
Decrease thrombin, EPCR, and protein S levels
Increase C-reactive protein production
Increase complement activation
Increase platelet count and reactivity
Chemokines Activate platelet aggregation and adhesion
Attract more leukocytes