Table 1 44 Signature Genes that are Interferon Related
From: Delayed polarization of mononuclear phagocyte transcriptional program by type I interferon isoforms
Gene | Function/Association | Alias | Induced by most IFN-α's | Induced by IFN-β | Ref |
|---|---|---|---|---|---|
SP110 | nuclear body protein | Interferon-induced protein 41/75 | yes | yes | 16 |
C1Orf29 | Unknown | Â | yes | yes | none |
ISG20 | IFN stimulated genes | HEM45 | yes | yes | 17–18 |
TNFSF13B | TFN superfamily | BAFF BAFF BLYS HGNC:13472 TALL-1 THANK TNFSF20 ZTNF4 (L | yes | yes | 19 |
ITGA5 | Integrin-alpha 5 (receptor for fibrinogen and fibronectin) | CD49e, FNRA, VLA5A, fibronectin receptor (alpha subunit), integrin alpha 5 | yes | yes | 20 |
Mx1 | Mixovirus resistence | Â | yes | no | 21 |
IFRG28 | IFN responsive, potential type III membrane protein | Â | yes | no | none |
CXCL10 | CXC family | C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, chemokine (C-X-C motif) ligand 10, gamma IP10 | yes | yes | 22,23 |
OAS2 | 2'5'OAS 2 | Â | yes | yes | 24 |
OAS1 | 2'5'OAS 1 | Â | yes | yes | 25 |
TRIM22 | STAF 50 | GPSTAF50, RNF94, STAF50-PEN, Stimulated Trans-Acting Factor | yes | yes | 25,26 |
UBE2L6 | Ubiquitin conjugated enzyme | MGC40331, RIG-B, UBCH8, retinoic acid induced gene B protein, ubiquitin carrier protein, ubiquitin-conjugating enzyme E2L 6, ubiquitin-protein ligase, Ubiquitin-conjugating enzyme | yes | yes | 27 |
Ly6E | Lymphocyte antigen complex | LY6, RIG-E, RIGE, SCA-2, SCA2, TSA-1 | yes | yes | 28 |
IFITM3 | IFN-induced transmembran protein | 1-8U | yes | no | 29,30 |
GMPR | Guanosine monophosp reductase | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP | yes | no | none |
PSME2 | PA28 Proteasome subunit | PA28B, PA28beta, REGbeta, 11S regulator complex beta subunit, MCP activator | yes | yes | 31, 32 |
PSMB9 | Proteasome subunit | LMP2, RING12 | yes | yes | 32 |
GBP1 | Binds GTP, GDP and GMP | Interferon-induced guanylate-binding protein 1 | yes | yes | 33 |
NUP155 | nucleoporin | KIAA0791, N155 | yes | yes | none |
CIG5 | antiviral protein induced by CMV | vig1, Viperin | yes | yes | 34 |
LAP3 | Signal transducer | HGNC:8843, LAP, LAPEP, PEPS | yes | yes | 35 |
Stat1 | Transcription factor that binds to the ISRE and GAS elements | ISGF-3, STAT91 | yes | yes | 36 |
PRIC 285 | helicase | FLJ00244, KIAA1769 | yes | yes | none |
TRAF5 | adapter protein and signal transducer | MGC:39780, RNF8 | yes | yes | none |
KIAA1268 | unknown | Â | yes | yes | none |
NTRK2 | tyrosine kinases receptor | TRKB | yes | yes | 37 |
ZC3HDC1 | zinc finger CCCH-type domain | Â | yes | yes | none |
BST2 | bone marrow stromal antigen | Â | yes | yes | none |
LIPC | lipase, hepatic | HL, HTGL, LIPH, lipase hepatic | yes | no | none |
IFI44 | interferon-induced, hepatitis C-associated microtubular aggregate protein | MTAP44 | yes | yes | 38 |
IFIT2 | IFN-α inducible protein | G10P2, GARG-39, IFI-54, IFI54, ISG-54K, cig42, Interferon alpha-inducible protein | yes | yes | 39, 40 |
G1P2 | IFN-α inducible protein, Ubiquitin cross-reactive protein precursor | IFI15, ISG15, UCRP | yes | yes | 27 |
G1P3 | IFN-α inducible protein | 6–16, IFI616, interferon, alpha-inducible protein | yes | no | 41 |
Mx2 | myxo resistance | Â | yes | no | 21 |
IFIT1 | IFN-α inducible protein | G10P1, GARG-16, IFI-56, IFI56, IFNAI1, RNM561 | yes | no | 42 |
PRKR | Interferon-induced, double-stranded RNA-activated protein kinase | EIF2AK1, PKR, interferon-inducible elF2alpha kinase | yes | yes | 43 |
OAS3 | 2'5'OAS 3 | p100, 2'-5'-oligoadenylate synthetase 3 | yes | yes | 24 |
LOC129607 | hypotetical protein | Â | yes | yes | none |
Cyclin E binding protein 1 | ubiquitin-protein ligase, regulation of cyclin dependent protein kinase activity | CEBP1, HECT E3 ubiquitin ligase | yes | no | 44 |
DXD58 | Retinoic acid-inducible gene | RIG-I, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | yes | no | 45 |
USP18 | ubiquitin specific protease 18 | ISG43, UBP43, ubiquitin specific protease 18 | yes | no | 46, 47 |
PRSS21 | protease serine, Could regulate proteolytic events associated with testicular germ cell maturation. | ESP-1, TEST1, testisin | yes | no | none |
IRF7 | IFN regulatory factor 7 | Â | yes | yes | 48 |
PLA2G4B | phospholipase A2 | CPLA2-BETA, HsT16992, PLA2G4B protein | yes | yes | 49 |