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Table 1 44 Signature Genes that are Interferon Related

From: Delayed polarization of mononuclear phagocyte transcriptional program by type I interferon isoforms

Gene Function/Association Alias Induced by most IFN-α's Induced by IFN-β Ref
SP110 nuclear body protein Interferon-induced protein 41/75 yes yes 16
C1Orf29 Unknown   yes yes none
ISG20 IFN stimulated genes HEM45 yes yes 17–18
TNFSF13B TFN superfamily BAFF BAFF BLYS HGNC:13472 TALL-1 THANK TNFSF20 ZTNF4 (L yes yes 19
ITGA5 Integrin-alpha 5 (receptor for fibrinogen and fibronectin) CD49e, FNRA, VLA5A, fibronectin receptor (alpha subunit), integrin alpha 5 yes yes 20
Mx1 Mixovirus resistence   yes no 21
IFRG28 IFN responsive, potential type III membrane protein   yes no none
CXCL10 CXC family C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, chemokine (C-X-C motif) ligand 10, gamma IP10 yes yes 22,23
OAS2 2'5'OAS 2   yes yes 24
OAS1 2'5'OAS 1   yes yes 25
TRIM22 STAF 50 GPSTAF50, RNF94, STAF50-PEN, Stimulated Trans-Acting Factor yes yes 25,26
UBE2L6 Ubiquitin conjugated enzyme MGC40331, RIG-B, UBCH8, retinoic acid induced gene B protein, ubiquitin carrier protein, ubiquitin-conjugating enzyme E2L 6, ubiquitin-protein ligase, Ubiquitin-conjugating enzyme yes yes 27
Ly6E Lymphocyte antigen complex LY6, RIG-E, RIGE, SCA-2, SCA2, TSA-1 yes yes 28
IFITM3 IFN-induced transmembran protein 1-8U yes no 29,30
GMPR Guanosine monophosp reductase Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP yes no none
PSME2 PA28 Proteasome subunit PA28B, PA28beta, REGbeta, 11S regulator complex beta subunit, MCP activator yes yes 31, 32
PSMB9 Proteasome subunit LMP2, RING12 yes yes 32
GBP1 Binds GTP, GDP and GMP Interferon-induced guanylate-binding protein 1 yes yes 33
NUP155 nucleoporin KIAA0791, N155 yes yes none
CIG5 antiviral protein induced by CMV vig1, Viperin yes yes 34
LAP3 Signal transducer HGNC:8843, LAP, LAPEP, PEPS yes yes 35
Stat1 Transcription factor that binds to the ISRE and GAS elements ISGF-3, STAT91 yes yes 36
PRIC 285 helicase FLJ00244, KIAA1769 yes yes none
TRAF5 adapter protein and signal transducer MGC:39780, RNF8 yes yes none
KIAA1268 unknown   yes yes none
NTRK2 tyrosine kinases receptor TRKB yes yes 37
ZC3HDC1 zinc finger CCCH-type domain   yes yes none
BST2 bone marrow stromal antigen   yes yes none
LIPC lipase, hepatic HL, HTGL, LIPH, lipase hepatic yes no none
IFI44 interferon-induced, hepatitis C-associated microtubular aggregate protein MTAP44 yes yes 38
IFIT2 IFN-α inducible protein G10P2, GARG-39, IFI-54, IFI54, ISG-54K, cig42, Interferon alpha-inducible protein yes yes 39, 40
G1P2 IFN-α inducible protein, Ubiquitin cross-reactive protein precursor IFI15, ISG15, UCRP yes yes 27
G1P3 IFN-α inducible protein 6–16, IFI616, interferon, alpha-inducible protein yes no 41
Mx2 myxo resistance   yes no 21
IFIT1 IFN-α inducible protein G10P1, GARG-16, IFI-56, IFI56, IFNAI1, RNM561 yes no 42
PRKR Interferon-induced, double-stranded RNA-activated protein kinase EIF2AK1, PKR, interferon-inducible elF2alpha kinase yes yes 43
OAS3 2'5'OAS 3 p100, 2'-5'-oligoadenylate synthetase 3 yes yes 24
LOC129607 hypotetical protein   yes yes none
Cyclin E binding protein 1 ubiquitin-protein ligase, regulation of cyclin dependent protein kinase activity CEBP1, HECT E3 ubiquitin ligase yes no 44
DXD58 Retinoic acid-inducible gene RIG-I, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 yes no 45
USP18 ubiquitin specific protease 18 ISG43, UBP43, ubiquitin specific protease 18 yes no 46, 47
PRSS21 protease serine, Could regulate proteolytic events associated with testicular germ cell maturation. ESP-1, TEST1, testisin yes no none
IRF7 IFN regulatory factor 7   yes yes 48
PLA2G4B phospholipase A2 CPLA2-BETA, HsT16992, PLA2G4B protein yes yes 49
  1. * Interferon γ only
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