Apo2L/TRAIL significantly inhibited the growth of pancreatic adenocarcinoma #1. Mice bearing patient tumor xenografts were treated with Apo2L/TRAIL and the tumor volumes on the final day of treatment (day 35) were compared (7 mice/group, the mean is indicated by the horizontal line; p = 0.004). B, C: Comparison of the histology of the median tumors. B. In the periphery of an untreated tumor, there are numerous large glands (arrow) containing secretory product. C. The treated tumor has fewer glands (arrow) and a higher proportion of connective tissue. There are also large pools of residual secretory product (S) that are not surrounded by epithelial cells.