From: Progress and controversies in developing cancer vaccines
• Limited by MHC restriction. |
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• Unique individual tumor-specific antigens difficult to include. |
• Rapid degradation in vivo. |
• Heterogeneity of tumor antigen expression. |
• Ignorance. We don't yet know how best to vaccinate with them. * |
• Clinical responses have been rare in most series (with peptide or any vaccine alone).* |