Progress and controversies in developing cancer vaccines

Table 1 Practical and Theoretical Advantages of Peptide vaccines for cancer

Characteristic	Detail	Advantage vs
		Tumor cell antigen sources	adoptive cellular therapy
Pure	Avoid tolerizing cellular antigens; exclude normal protein, avoid autoimmunity.	X
Processed	Avoid effects of immunoproteasome	X
Cheap	Feasible to study without corporate support	X	X
Easier	Lower regulatory hurdles	X	X
Evaluable	Excellent cancer vaccine model, allowing direct evaluation of response to the specific immunogen	X
Modifiable	Create synthetic peptides better than native peptides	X
Immunogenic	Induce T cell responses in patients
Combinable	Multipeptide vaccines may mimic immune effects of whole cell vaccines.

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