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Table 1 Practical and Theoretical Advantages of Peptide vaccines for cancer

From: Progress and controversies in developing cancer vaccines

Characteristic Detail Advantage vs
   Tumor cell antigen sources adoptive cellular therapy
Pure Avoid tolerizing cellular antigens; exclude normal protein, avoid autoimmunity. X  
Processed Avoid effects of immunoproteasome X  
Cheap Feasible to study without corporate support X X
Easier Lower regulatory hurdles X X
Evaluable Excellent cancer vaccine model, allowing direct evaluation of response to the specific immunogen X  
Modifiable Create synthetic peptides better than native peptides X  
Immunogenic Induce T cell responses in patients   
Combinable Multipeptide vaccines may mimic immune effects of whole cell vaccines.