Is Melanoma a stem cell tumor? Identification of neurogenic proteins in trans-differentiated cells

Table 1 Proteins Expressed Exclusively in Neuronal Cells

Protein Name	Abbreviation	Accession #	Functional Category
Acetylcholinesterase precursor	ACES	O62763	Membrane Enzyme
Beta-2 adrenergic receptor	B2AR	Q9TST5	Membrane Receptor
Beta-hexosaminidase beta chain precursor	HEXB	P49614	Lysosomal Enzyme
Interleukin-1 receptor beta precursor	IL1B	P41687	Cytokine Receptor
Interleukin-2 receptor alpha chain precursor	IL2A*	P41690	Cytokine Receptor
Interleukin-6 precursor	IL6*	P41683	Cytokine
Interferon gamma precursor	ING	P46402	Cytokine
Macrophage colony stimulating factor I receptor precursor	KFMS	P13369	Membrane tyrosine kinase Receptor
Major allergen I polypeptide chain 2 precursor	FEL2	P30440	Cytoplasmic Cat Allergen
Lipoprotein lipase precursor	LIPL	P55031	Membrane Enzyme
Red-sensitve opsin	OPSR	O18913	Sensory Retinal protein
Proto-oncogene serine/threonine-protein kinase pim-1	PIM1*	Q95LJ0	Serine Threonine Kinase
B:
Proteins Expressed Exclusively in Melanoma cells
Protein Name	Abbreviation	Accession #	Functional Category
Cyclin-dependent kinase inhibitor 1	CDNA**	O19002	Nuclear Cell Cycle Protein
Matrilysin precursor	MMO7	P55032	Membrane Enzyme

A: shows 12 proteins that were expressed exclusively in neuronal cells (ACES, B2AB, FEL-2, HEXB, IL1B, IL2A*, IL6*, ING, KFMS, LIPL, CPSR and PIM1). One asterisk (*) indicates that the protein is detected in single, non-complexed form in neuronal cells only. B: lists two proteins (CDNA** and MMO7) that were expressed exclusively in melanoma (i.e. not detected in trans-differentiated neuronal cells. Two asterisks (**) indicate that the protein is detected in single, non-complexed form in melanoma cells only.

ISSN: 1479-5876