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Table 1 Genes differentially expressed in antibody-treated versus untreated BT474 cell

From: Influence of immunomagnetic enrichment on gene expression of tumor cells

Genes

GenBank Accession#

Ratio*

Extracellular matrix remodeling:

  

COL11

J04177

- 6.2

MMP17

X89576

- 4.7

MMP16

D50477

-4.6

SPARC

J03040

5.7

Adhesion:

  

PKD1

U24497

- 7.3

NCAM

AF002246

7.3

M-cadherin

D83542

3.5

Cytoskeleton plasticity:

  

SPTA1

M61877

7.4

Signal transduction:

  

RGS4

U27768

- 10.1

GAS

L13720

- 7.1

BMP1

U50330

- 7.0

FGFR4

L03840

- 6.5

PMEL17

M77348

- 6.5

ETS-1

 

- 5.9

ERBB2

M95667

- 5.8

TGF-beta

X02812

- 5.2

N-ras

X02751

- 4.8

HRS

D84064

- 4.7

KIR

U10550

9.0

BMP6

M60315

7.5

BIN1

U68485

7.4

SGI

Y00064

4.1

CDC7

AF015592

3.8

CNTF

S72921

3.4

SH3BP2

AF000936

3.1

Apoptosis:

  

CD27BP

U82938

6.0

DR5

F016268

4.8

Metabolism:

  

PPAT

U00238

6.3

HPRT

P00492

5.4

Immune response:

  

MHC class I

U65416

8.4

Replication/repair/transcription:

  

CHAF1A

U20979

- 12.3

NEK3

Z29067

- 5.6

BTG

U72649

8.9

HRC1

M91083

6.2

TOP1

J03250

4.9

CLK1

L29222

4.0

Functionally unclassified

  

PIG7

AF010312

- 4.9

menin

U93236

3.1

  1. *Ratio of normalized data from antibody-treated versus untreated BT474 cells as described in the Materials and Methods section. Negative values indicate downregulated and positive values upregulated genes.