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Table 3 Human genes belonging to Leukocyte Antigen 6 (Ly-6) gene super family

From: CD177: A member of the Ly-6 gene superfamily involved with neutrophil proliferation and polycythemia vera

Gene Cellular expression # Cysteine domains Type of protein Comments Location
CD59 Erythrocytes 1 GPI-anchored Protects cells from membrane attack complex induced lysis 11p13
PSCA Prostate 1 GPI-anchored Marker of prostate cancer and increase prostate cell division 8q24.2
SLURP-1 (ARS B)   1 Secreted Mutations are associated with Mal de Meleda syndrome 8q24.3
SLURP-2   1 Secreted Increased expression in skin keratinocytes in psoriasis vulgaris 8q24.3
E-48 (LY6D) Keratinocytes 1 GPI-anchored Overexpressed in head-and-neck squamous cell carcinoma 8q24.3
RIG-E Acute promyelocytic leukemia cells 1 GPI-anchored Expression is induced by all-trans-retinoic acid 8q24.3
LY6H Brain and acute lymphoblastic leukemia 1 GPI-anchored   8q24.3
LYGK Keratinocytes 1 GPI-anchored Overexpressed in head-and-neck squamous cell carcinoma  
GML   1 GPI-anchored Expression is induced by suppressor gene p53 8q24.3
SP-10 Sperm and testis 1 GPI-anchored Abnormal RNA splicing is common 11q23-q24
SAMP14 Spermatozoan 1 GPI-anchored   19q13.33
CD177 Neutrophil 2 GPI-anchored Increased expression in polycythemia vera 19q13.2
uPAR Neutrophils and monocytes 3 GPI-anchored A high affinity receptor for urokinase type plasminogen activator 19q13.3
  1. PSCA = Prostate Stem Cell Antigen SLURP-1 = Secreted Ly-6/uPAR Related Protein 1 SLURP-2 = Secreted Ly-6/uPAR Related Protein 2 SAMP14 = Sperm Acrosomal Membrane-Associated Protein 14