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Table 4 Selected genes constitutively expressed by RCC and melanoma metastases.

From: Melanoma-restricted genes

UNIQID

NAME

Extended Name

Median log2Cy5/Cy3

Averagelog2Cy5/Cy3

t-test*

   

RCC

MEL

OTH

RCC

MEL

OTH

p2-value

274276

IFIT2

interferon-induced protein with tetratricopeptide repeats 2

0.74

0.30

-0.28

0.54

0.18

-0.23

0.06

191173

ITGB7

integrin, beta 7

0.17

0.33

-0.26

0.14

0.30

-0.26

0.51

191169

FLT3LG

fms-related tyrosine kinase 3 ligand

0.18

0.32

-0.27

0.31

0.19

-0.20

0.53

187264

CORO1A

coronin-like protein p57=actin binding protein p57

0.38

0.13

-0.19

0.47

0.12

-0.17

0.16

189684

SP110

SP110 nuclear body protein

0.22

0.60

-0.56

0.26

0.44

-0.42

0.27

279561

TNFRSF7

CD27

-0.06

0.65

-0.39

-0.09

0.45

-0.35

0.07

279871

CD37

CD37 antigen

0.09

0.56

-0.56

0.33

0.47

-0.38

0.72

276143

TAP2

transporter 2

0.23

0.33

-0.21

0.27

0.31

-0.24

0.86

281103

 

sialic acid binding Ig-like lectin 7=D-siglec=expressed in dendritic cells

0.33

0.26

-0.34

0.27

0.24

-0.24

0.86

279699

BTK

btk = Bruton agammaglobulinemia tyrosine kinase ||

-0.04

0.45

-0.28

-0.09

0.34

-0.26

0.05

274604

CST7

cystatin F (leukocystatin) ||

-0.14

0.37

-0.29

-0.07

0.45

-0.34

0.06

281440

ITGB7

CD103 beta=Integrin beta 7 ||

0.36

0.39

-0.25

0.31

0.38

-0.35

0.67

191157

KLRG1

killer cell lectin-like receptor subfamily G, member 1 ||

0.32

0.40

-0.17

0.35

0.23

-0.25

0.39

274016

RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated) ||

0.48

0.38

-0.29

0.36

0.30

-0.29

0.78

274444

ITGAL

integrin, alpha L (antigen CD11A (p180)|

0.34

0.57

-0.43

0.30

0.33

-0.31

0.88

282504

CX3CR1

chemokine (C-X3-C motif) receptor 1

0.84

0.66

-0.53

0.62

0.51

-0.50

0.76

274267

KLRK1

killer cell lectin-like receptor subfamily K, member 1

0.80

0.33

-0.20

0.71

0.34

-0.38

0.14

187290

LILRB1

LIR-7=PIR homologue|

0.11

0.67

-0.15

0.12

0.49

-0.41

0.20

186380

SLC2A3

solute carrier family 2 (facilitated glucose transporter), member 3

0.14

0.34

-0.21

0.34

0.36

-0.34

0.94

188111

CD3Z

CD3Z antigen, zeta polypeptide (TiT3 complex)

0.09

0.42

-0.30

-0.01

0.35

-0.27

0.10

186528

SLA

SLAP=src-like adapter protein

0.38

0.31

-0.24

0.32

0.33

-0.31

0.98

185279

ASGR2

asialoglycoprotein receptor 2|

0.28

0.61

-0.33

0.17

0.45

-0.40

0.16

187450

LILRB2

leukocyte immunoglobulin-like receptor, subfamily B, member 2

0.10

0.65

-0.45

0.13

0.54

-0.44

0.07

184382

FGR

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog|

0.57

0.23

-0.29

0.40

0.27

-0.28

0.49

190623

MYO1F

myosin IF|

0.18

0.50

-0.22

0.16

0.46

-0.38

0.24

188800

PILRA

paired immunoglobin-like type 2 receptor alpha

0.16

0.56

-0.08

0.07

0.31

-0.27

0.17

188004

CLC

Charcot-Leyden crystal protein|

0.08

0.51

-0.33

0.08

0.53

-0.44

0.08

186399

PPP3CC

protein phosphatase 3, catalytic subunit, gamma isoform (calcineurin A gamma)|

0.07

0.36

-0.15

0.05

0.21

-0.18

0.17

278997

XLHSRF-1

heat shock regulated 1

-0.12

0.32

-0.09

0.10

0.28

-0.20

0.33

281827

LLT1

lectin-like NK cell receptor

0.46

0.26

-0.33

0.53

0.22

-0.26

0.08

282466

LLT1

lectin-like NK cell receptor

0.22

0.38

-0.23

0.23

0.32

-0.32

0.66

189527

FMNL1

formin-like 1

0.46

0.43

-0.25

0.44

0.24

-0.26

0.32

282550

 

natural killer cell transcript 4

-0.20

0.41

-0.29

0.00

0.30

-0.24

0.15

282534

 

B-cell CLL/lymphoma 2

0.05

0.38

-0.38

-0.05

0.33

-0.34

0.05

282477

ICOS

inducible T-cell co-stimulator|

-0.07

0.37

-0.18

-0.07

0.28

-0.26

0.07

282624

granzyme A

granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)|

-0.10

0.58

-0.33

-0.16

0.43

-0.31

0.06

  1. * Two-tailed un-paired t test between RCC and MEL samples. RCC = Renal cell carcinoma; Mel = melanoma lesions; Oth = all other tumors in the study (see Table I).