Table 3 Specific A locus sequence-based typing ambiguities discovered during this study and the reason that the ambiguity occurs.
1 | A*010101/04N | 0104N is resolved as a C insertion at bp 628 in exon 4. |
|---|---|---|
2 | A*2402/09N/11N | 24020101 is unresolvable from 24020102L. 2409N is resolved in exon 4 at bp 742 by a T substitution. The base change responsible for 2409N creates a premature termination on exon 4. 2411N is the result of the same insertion at 0104N. |
3 | A*010101/04N, 0201/09/43N or 0236, 3604 | 0209 is resolved as an A substitution in exon 4 at bp 779. 0243N is resolved as a C insertion at bp 780. 0236 and 3604 are not defined in exon 4. |
4 | A*020101/43N, 030101 or 0226, 0307 or 0234, 0308 | 0226 and 0308 are not defined in exon 4. As a result resolution can not be determined. |
5 | A*0201/09/43N, 2301/07N or 0236, 2304 | The 02 alleles are resolved in exon 4 as described above. 2307 N is resolved by a C insert at bp 628 in exon 4. Neither 0236 nor 2304 are defined in exon 4. |
6 | A*020101/09/43N, 240201/09N/11N or 0212, 2413 or 0236, 24031/33 | The 02 and 24 alleles are resolved in exon 4 as described above. Alleles 2413 and 0236 are not defined in exon 4. |
7 | A*0201/09, 2501 or 0206, 2503 | The 02 alleles are resolved in exon 4 as described above. 2503 is not defined in exon 2. |
8 | A*030101, 240201/09N/11N or 0308, 2407 | The 24 alleles are resolved in exon 4 as described above. 0308 is not defined in exon 4. |
9 | A*030101/2501 or 0308/2502 or 3204/6601 | 0308, 2502, and 3204 are not defined in exon 4. |
10 | A*A*030101, 2601 or 0308, 2613 | 0308 and 2613 are not defined in exon 4. |
11 | A*240201/09N/11N, 2601 or 2406, 2608 | The 24 alleles are resolved in exon 4 as described above. 2406 is undefined in exon 4. |
12 | A*240201/09N/11N, 2902 or 24031, 2903 | The 24 alleles are resolved in exon 4 as described above. 24020101, 2902 and 240301, 2903 are unresolved. |
13 | A*020101/09/20/43N, 310102/3102 | 3102 is not defined in exon 4. |
14 | A*240201/09N/11N, 3201 or 2432, 3203 | Both 2432 and 3203 are not defined in exon 4. |
15 | A*240201/09N/11N, 680102/11N or 2406, 6809 or 2407, 680301 | 680102 and 6811N are not resolvable. 2406 and 6809 are not defined in exon 4. Exon 4 would resolve 24020101 from 2409N and 2411N. 24020101, 680102/11N is unresolvable from 2407, 680301. |
16 | A*2502, 7401 or 2502, 7402 or 3201, 6601 | 7402 is not defined in exon 4. 2502, 7401 is unresolvable from 3201, 6601. |