Genetic polymorphisms of CYP2A13 and its relationship to nasopharyngeal carcinoma in the Cantonese population

Table 3 SNP frequency of CYP2A13 gene in NPC cases and controls

Nucleotide change	Amino acid change	Case		Control		OR(95% CI)
		No	%	No	%
74 G>A^a	Arg25Gln	58/472(Het)	12.3	99/709(Het)	14.0	0.86 (0.60–1.24)
		4/472(Hom)	0.9	6/709(Hom)	0.9	1.00 (0.24–4.02)
281A>G^c	Intron	8/211(Het)	3.8	7/177(Het)	4.0	0.96 (0.31–3.00)
446 T>C^d	Intron	0/211	0.0	2/177(Het)	1.1	Fisher exact p = 0.21
578C>T	Arg101OPA	1/211(Het)	0.5	0/177	0.0	Fisher exact p = 1.00
3375 C>T^b	Arg257Cys	57/472(Het)	12.1	99/709(Het)	14.0	0.85 (0.59–1.22)
		4/472(Hom)	0.9	6/709(Hom)	0.9	1.00 (0.24–4.02)
7196 C>T	Intron	4/211(Het)	1.9	6/177(Het)	3.4	0.55 (0.13–2.24)
7233 T>G	Intron	29/211(Het)	13.7	26/177(Het)	14.7	0.92(0.50–1.70)
		3/211(Hom)	1.4	6/177(Hom)	3.4	0.41(0.08–1.88)

Notes: Het: heterozygote; Hom: homozygote; a: Determined by mismatch PCR-RFLP; b: Determined by PCR-RFLP; Other SNPs were determined by sequencing; c: Haplotype 281A>G, 396A>G, 419G>A, 424G>A, 441C>T, 672C>A, 6958C>T, 7233T>G was represented by 281A>G in the Table; d: three SNPs (446T>C, 447G>A, 454A>T) were simultaneously observed as heterozygote in 2 samples, so they were represented by 446T>C in the table.

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