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Table 1 Chemokines/Receptors in EOC

From: Peritoneal inflammation – A microenvironment for Epithelial Ovarian Cancer (EOC)

Ligand (Alt. Name) Receptors Cells Targeted Correlates in EOC
CCL2 (MCP1) *+ CCR2 Activated T, Monocytes, DC, Basophils CD8+ T cells, CD68+ MA ↓ on ascitic MA
CCL3 (MIP1α)*+ CCR2 Activated T, NK, MO, Eosinophils  
CCL4 (MIP1β)*+ Unknown   
CCL5 (RANTES) * CCR2 Activated T, NK, MO, Eosinophils  
CCL7 (MCP3) + CCR2   
CCL18 (PARC) + Unknown   MA produced but not induced in EOC cells
CXCL8 (IL8) *+ CXCR1, CXCR2 Neutrophils, Resting T  
CXCL12 (SDF1) *+ CXCR4 Neutrophils, Resting T, Activated T, B, MO CXCR4 preferentially expressed on EOC cells
  1. * In RNA detected on EOC cell lines + Proteins detected in ascites