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Table 1 Chemokines/Receptors in EOC

From: Peritoneal inflammation – A microenvironment for Epithelial Ovarian Cancer (EOC)

Ligand (Alt. Name)

Receptors

Cells Targeted

Correlates in EOC

CCL2 (MCP1) *+

CCR2

Activated T, Monocytes, DC, Basophils

CD8+ T cells, CD68+ MA ↓ on ascitic MA

CCL3 (MIP1α)*+

CCR2

Activated T, NK, MO, Eosinophils

 

CCL4 (MIP1β)*+

Unknown

  

CCL5 (RANTES) *

CCR2

Activated T, NK, MO, Eosinophils

 

CCL7 (MCP3) +

CCR2

  

CCL18 (PARC) +

Unknown

 

MA produced but not induced in EOC cells

CXCL8 (IL8) *+

CXCR1, CXCR2

Neutrophils, Resting T

 

CXCL12 (SDF1) *+

CXCR4

Neutrophils, Resting T, Activated T, B, MO

CXCR4 preferentially expressed on EOC cells

  1. * In RNA detected on EOC cell lines + Proteins detected in ascites