Skip to main content

Table 5 Soluble factor (pg/ml) concentrations in the serum of 10 patients who completed the study (only factors that demonstrated significant changes in concentration after the 4th dose compared with before therapy are shown)

From: Forecasting the cytokine storm following systemic interleukin (IL)-2 administration

Soluble Factor

Average before IL-2

STD error before IL-2

Average after 4 doses

STD error after 4 doses

p value before vs. after 4 doses

Bonferroni correction

IL2*

0

0

1426

394

0.00410

0.24205

MCP2

32

9

296

34

0.00001

0.00047

I309

18

4

222

25

0.00001

0.00070

IP10

146

18

2940

390

0.00003

0.00178

VegF

865

131

1411

132

0.00003

0.00191

ITAC

29

4

438

57

0.00003

0.00200

TNFR1

1641

112

6067

651

0.00004

0.00207

IFNγ

149

21

246

16

0.00004

0.00234

IL15

0

0

14

2

0.00005

0.00269

MCP1

984

227

31267

4583

0.00006

0.00367

MIP3b

142

17

33836

5140

0.00007

0.00405

Lymph

111

22

639

95

0.00010

0.00571

E-Selectin

106029

5703

377934

40503

0.00011

0.00638

TARC

248

59

8993

1517

0.00015

0.00867

SDF1b

62

21

883

142

0.00018

0.01045

MMP8

1187

455

5081

927

0.00024

0.01406

MCP3

10

1

53

8

0.00029

0.01685

MDC

586

111

1272

214

0.00031

0.01841

Eotaxin

115

22

392

67

0.00032

0.01890

TIMP2

75277

5629

108359

4266

0.00033

0.01949

Exodus2

419

71

1108

157

0.00049

0.02911

MMP13

839

221

1742

171

0.00055

0.03224

TIMP1

198383

20136

1021646

178036

0.00071

0.04194

TNFa

521

65

839

74

0.00086

0.05090

MIP1b

512

205

4072

794

0.00105

0.06189

TNFR2

3195

259

16353

3113

0.00115

0.06774

HGF

8281

2359

17298

1311

0.00251

0.14822

IL5

0

0

40

10

0.00274

0.16167

MMP9

233004

43617

657077

142793

0.00391

0.23066

IL7

2

1

6

2

0.00508

0.29968

MMP2

210099

37913

399516

50101

0.00510

0.30111

MMP10

1467

220

3247

528

0.00545

0.32168

MCP4

84

19

1663

495

0.00698

0.41181

IL10

3

1

179

54

0.00707

0.41723

MIP3a

18

4

1346

414

0.00784

0.46274

IL6

50

5

608

184

0.01139

0.67211

VCAM1

310701

30008

1278753

336280

0.01248

0.73618

MMP3

27613

6960

59390

16227

0.01433

0.84561

KGF

373

117

505

109

0.01473

0.86914

ICAM1

499363

62669

2313052

682964

0.01505

0.88787

IL6R

23556

1882

19437

1316

0.02143

1.26450

IL4

0

0

5

2

0.02359

1.39181

IL8

61

4

296

90

0.02410

1.42202

IL18

67

11

167

43

0.03041

1.79442

IL16

13

6

104

43

0.04344

2.56278

MIP1a

2952

143

3160

156

0.05446

3.21343

  1. Soluble Factors (pg/ml) present in the serum of patients undergoing high dose IL-2 immunotherapy were averaged before and after 4 doses of IL-2. A paired 2-tailed student t test was used to assess significance with an arbitrary cutoff of p = 0.05. Bonferroni's correction was applied to the data set by correcting for a total of 59 soluble factors (IL-2 was not factored in); IL-2 levels were included as internal control (*) since these values reflect in part administered human recombinant IL-2.