From: Forecasting the cytokine storm following systemic interleukin (IL)-2 administration
Soluble Factor | Average before IL-2 | STD error before IL-2 | Average after 4 doses | STD error after 4 doses | p value before vs. after 4 doses | Bonferroni correction |
---|---|---|---|---|---|---|
IL2* | 0 | 0 | 1426 | 394 | 0.00410 | 0.24205 |
MCP2 | 32 | 9 | 296 | 34 | 0.00001 | 0.00047 |
I309 | 18 | 4 | 222 | 25 | 0.00001 | 0.00070 |
IP10 | 146 | 18 | 2940 | 390 | 0.00003 | 0.00178 |
VegF | 865 | 131 | 1411 | 132 | 0.00003 | 0.00191 |
ITAC | 29 | 4 | 438 | 57 | 0.00003 | 0.00200 |
TNFR1 | 1641 | 112 | 6067 | 651 | 0.00004 | 0.00207 |
IFNγ | 149 | 21 | 246 | 16 | 0.00004 | 0.00234 |
IL15 | 0 | 0 | 14 | 2 | 0.00005 | 0.00269 |
MCP1 | 984 | 227 | 31267 | 4583 | 0.00006 | 0.00367 |
MIP3b | 142 | 17 | 33836 | 5140 | 0.00007 | 0.00405 |
Lymph | 111 | 22 | 639 | 95 | 0.00010 | 0.00571 |
E-Selectin | 106029 | 5703 | 377934 | 40503 | 0.00011 | 0.00638 |
TARC | 248 | 59 | 8993 | 1517 | 0.00015 | 0.00867 |
SDF1b | 62 | 21 | 883 | 142 | 0.00018 | 0.01045 |
MMP8 | 1187 | 455 | 5081 | 927 | 0.00024 | 0.01406 |
MCP3 | 10 | 1 | 53 | 8 | 0.00029 | 0.01685 |
MDC | 586 | 111 | 1272 | 214 | 0.00031 | 0.01841 |
Eotaxin | 115 | 22 | 392 | 67 | 0.00032 | 0.01890 |
TIMP2 | 75277 | 5629 | 108359 | 4266 | 0.00033 | 0.01949 |
Exodus2 | 419 | 71 | 1108 | 157 | 0.00049 | 0.02911 |
MMP13 | 839 | 221 | 1742 | 171 | 0.00055 | 0.03224 |
TIMP1 | 198383 | 20136 | 1021646 | 178036 | 0.00071 | 0.04194 |
TNFa | 521 | 65 | 839 | 74 | 0.00086 | 0.05090 |
MIP1b | 512 | 205 | 4072 | 794 | 0.00105 | 0.06189 |
TNFR2 | 3195 | 259 | 16353 | 3113 | 0.00115 | 0.06774 |
HGF | 8281 | 2359 | 17298 | 1311 | 0.00251 | 0.14822 |
IL5 | 0 | 0 | 40 | 10 | 0.00274 | 0.16167 |
MMP9 | 233004 | 43617 | 657077 | 142793 | 0.00391 | 0.23066 |
IL7 | 2 | 1 | 6 | 2 | 0.00508 | 0.29968 |
MMP2 | 210099 | 37913 | 399516 | 50101 | 0.00510 | 0.30111 |
MMP10 | 1467 | 220 | 3247 | 528 | 0.00545 | 0.32168 |
MCP4 | 84 | 19 | 1663 | 495 | 0.00698 | 0.41181 |
IL10 | 3 | 1 | 179 | 54 | 0.00707 | 0.41723 |
MIP3a | 18 | 4 | 1346 | 414 | 0.00784 | 0.46274 |
IL6 | 50 | 5 | 608 | 184 | 0.01139 | 0.67211 |
VCAM1 | 310701 | 30008 | 1278753 | 336280 | 0.01248 | 0.73618 |
MMP3 | 27613 | 6960 | 59390 | 16227 | 0.01433 | 0.84561 |
KGF | 373 | 117 | 505 | 109 | 0.01473 | 0.86914 |
ICAM1 | 499363 | 62669 | 2313052 | 682964 | 0.01505 | 0.88787 |
IL6R | 23556 | 1882 | 19437 | 1316 | 0.02143 | 1.26450 |
IL4 | 0 | 0 | 5 | 2 | 0.02359 | 1.39181 |
IL8 | 61 | 4 | 296 | 90 | 0.02410 | 1.42202 |
IL18 | 67 | 11 | 167 | 43 | 0.03041 | 1.79442 |
IL16 | 13 | 6 | 104 | 43 | 0.04344 | 2.56278 |
MIP1a | 2952 | 143 | 3160 | 156 | 0.05446 | 3.21343 |