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Figure 1 | Journal of Translational Medicine

Figure 1

From: Endothelin receptors as novel targets in tumor therapy

Figure 1

The ET-1/ETAR autocrine pathway is biologically relevant in tumor development and progression modulating cell proliferation, survival, angiogenesis, invasion. Targeted blockade of the ETAR using the potent and selective ETAR antagonist reduces tumor growth which concurs with the inhibition of the tumor-induced angiogenesis and invasiveness and with the induction of massive tumor cell apoptosis.

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