Table 2 Classification of defined immunogens in cancer
From: Tumor antigens for cancer immunotherapy: therapeutic potential of xenogeneic DNA vaccines
Antigens | Examples | References |
|---|---|---|
Unique antigens (usually caused by mutations) | p53, ras, β-catenin, CDK4, CDC27, α actinin-4 | 32, 34, 36, 37, 38, 39 |
Differentiation antigens | Tyrosinase, TRP1/gp75, TRP2, gp100, Melan-A/MART1, gangliosides, PSMA | 42, 43, 44, 48, 50, 51 |
Overexpressed antigens | HER2, WT1, EphA3, EGFR, CD20 | 55, 59, 60, 61, 62 |
Cancer-testis antigens | MAGE, BAGE, GAGE, NY-ESO-1 | 63, 64 |
Universal antigens | Telomerase, Survivin | 19, 20 |