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Figure 1 | Journal of Translational Medicine

Figure 1

From: Tumor antigens for cancer immunotherapy: therapeutic potential of xenogeneic DNA vaccines

Figure 1

Methods of antigen presentation that could generate an immune response after DNA immunization. DNA can directly transfect dendritic cells (DCs) which can migrate to the draining lymph node to activate naïve T cells. Alternately, they can be cross primed when they uptake antigen from dying keratinocytes or myocytes. They can activate both CD8+ and CD4+ cells in the lymph node via Class I or Class II peptide-MHC complexes. Abbreviations – DCs dendritic cells, APC Antigen presenting cells, MHC Major Histocompatibility Complex, TcR T Cell Receptor Complex

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