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Table 1 Additional resources integrated into the COPDKB.

From: The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research

Resource Information type Number of nodes Number of associations
BioBridge omics network 2012 BioBridge 8w training extended by protein and metabolite measurements 4878 11448
Co-morbidity network Co-morbidity network from OMIM gene-disease associations as well as Medicare and Swedish health system patient data 8 435 3 973 126
COPD literature mining GWAS and epigenetic gene- disease associations 18 20
Disease grouping Expert-based manual grouping of diseases 493 diseases 27 groups
Human angiogenesis young, old Public, angiogenesis-related expression data 3691 3782
ICD 9 International classification of disease, ninth revision 13 222  
ICD 10 International classification of disease, tenth revision 12 416  
ITFP Transcription factors and targets 2 143 TF, 6 710 targets 74 907
MeSH Medical subject headings 24 767  
miRbase micro RNA 2024 human miRNA  
miRTarBase microRNA targets 12 194 human targets 38 311
Mouse inactivity-induced muscle wasting Public mouse, inactivity-induced muscle wasting data gene expression GSE25908, 15 287 154 597
PAC-COPD Clinical study 342 patients, 260 clinical attributes  
Pathway network Jaccard index based clustering of pathways from KEGG, Reactome and the BioBridge COPD text mining 1138 pathways 1815 associations
SNOMED-CT Systematized Nomenclature of Medicine -- Clinical Terms 296 519  
  1. Data sources added since the first release of the COPDKB