Software architecture. Integrative UML-like diagram representing the organisational, infrastructural and informational view of the software architecture. All modules communicate based on WebServices. The COPDKB provides information of type model, model paramters, parameter values (summarised as "simulation knowledge") and experimental data to the SE. The SE feeds back simulation results. With the CDSS the COPDKB exchanges requests for information on knowledge about co-morbidities and drug-interactions and provides corresponding search results. COPDKB = COPD Knowledge Base, SE = Simulation Environment, CDSS = Clinical Decision Support System, API = Application Programming Interface.