Figure 2
From: Systems Medicine: from molecular features and models to the clinic in COPD
Mechanistic Models and extensions. (a) Oxygen transport and utilization model (M1). (b) Mitochondrial respiration and reactive-oxygen species generation model (M2). (3) Personalized model of M2: M2 model is personalized by a Bayesian network that predicts the values of UQCR2 (oxidative phosphorylation chain) by inflammation-associated measurements (IL11RA and TNFRSF25). All models can be simulated in the Simulation Environment [58] and the patient specific values can be obtained through a COPD Knowledge Based [7].