Figure 5

Metabolic analysis. Upper panel: Resting individual metabolic profiles in COPD patients (spheres) and in healthy sedentary subjects (cubes), including pre (black symbols) - and post -training data (grey symbols). The results are expressed by the three Latent Variables (LV1, 2 and 3) of the partial-least square discriminant analysis (PLS-DA). The percentages indicate the magnitude of the differences between the two groups of subjects for each dimension (p<0.05). Bottom panel: Endurance training responses of individual metabolites. Mean training-induced responses of individual metabolites. Data expressed as percent of change are indicated as mean ± SEM. (*p<0.001; ^† p<0.01; ^‡ p<0.05) (reproduced from [27]with permission)