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Table 3 Correlation between grades of toxicity and different genotypes

From: Thymidylate synthase polymorphisms in genomic DNA as clinical outcome predictors in a European population of advanced non-small cell lung cancer patients receiving pemetrexed

Global distribution polymorphisms (Pol) No toxicity Grade 1-2 Grade 3-4 p value
VNTR polymorphisms
2R/2R 2 (22.2) 4 (44.2) 3 (33.4) 0.545
3R/3R 2 (25) 5 (75) 0 (0)
2R/3R 2 (25) 4 (50) 2 (25)
3R/4R 1 (100) 0 (0) 0 (0)
SNP polymorphisms
Absence 3 (42.9) 4 (57.1) 0 (0) 0.3
Presence 4 (22.2) 9 (50) 5 (27.8)
3′-UTR polymorphisms
+6/+6 3 (25) 6 (50) 3 (25) > 0.05
+6/-6 3 (27.3) 6 (54.5) 2 (18.2)
-6/-6 1 (50) 1 (50) 0 (0)