Figure 1From: Role of estrogen in hepatocellular carcinoma: is inflammation the key? Four types of ER-α variants in the liver. Alternative splicing events generate several different isoforms of ER-α. In the liver, all types of ER-α have been reported and play a role in HCC. These variants are mainly AF-1- or HBD-depleted. ERα-36 has an additional 27-amino-acid sequence at its COOH terminus.Back to article page