Table 6 A few representative KEGG pathways for the putative target genes of the validated miRNAs
KEGG pathway | Target genes | miRNAs |
|---|---|---|
TGF-beta signaling pathway | ACVR1C, INHBB,SMAD1, SMAD3, TGFBR2,ZFYVE9 | miR-26a-5p, miR-145-5p |
MAPK signaling pathway | KRAS, MAP3K7, DUSP6, FLNB, PPP3CA, PRKX, RASA1, TGFBR2,MAP4K4, RAPGEF2 | miR-143-3p, miR-145-5p |
mTORsignaling pathway | EIF4E | miR-4484 |
VEGF signaling pathway | KRAS, SHC2 | miR-143-3p, miR-4484 |
Calcium signaling pathway | ADCY3 | miR-4484 |
Wntsignaling pathway | PLCB1, FRAT2, GSK3B, PPP3CB | miR-26a-5p |
Gap junction | KRAS, ADCY3 | miR-143-3p, miR-4484 |
Regulation of actin cytoskeleton | PFN2, ITGA6, ITGB8, KRAS | miR-133b, miR-143-3p |
Hypertrophic cardiomyopathy (HCM) | IGF1, TPM3, TPM4 | miR-1 |
Tight junction | MPP5, RRAS2, VAPA, PPP2CB, KRAS | miR-1, miR-23b-3p, miR-133b, miR-143-3p |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | GJA1, ITGA6, SGCB, ITGB8, ACTB, ACTG1 | miR-1, miR-30c-5p, miR-145-5p |