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Table 6 A few representative KEGG pathways for the putative target genes of the validated miRNAs

From: Comparative expression profiles of microRNA in left and right atrial appendages from patients with rheumatic mitral valve disease exhibiting sinus rhythm or atrial fibrillation

KEGG pathway Target genes miRNAs
TGF-beta signaling pathway ACVR1C, INHBB,SMAD1, SMAD3, TGFBR2,ZFYVE9 miR-26a-5p, miR-145-5p
MAPK signaling pathway KRAS, MAP3K7, DUSP6, FLNB, PPP3CA, PRKX, RASA1, TGFBR2,MAP4K4, RAPGEF2 miR-143-3p, miR-145-5p
mTORsignaling pathway EIF4E miR-4484
VEGF signaling pathway KRAS, SHC2 miR-143-3p, miR-4484
Calcium signaling pathway ADCY3 miR-4484
Wntsignaling pathway PLCB1, FRAT2, GSK3B, PPP3CB miR-26a-5p
Gap junction KRAS, ADCY3 miR-143-3p, miR-4484
Regulation of actin cytoskeleton PFN2, ITGA6, ITGB8, KRAS miR-133b, miR-143-3p
Hypertrophic cardiomyopathy (HCM) IGF1, TPM3, TPM4 miR-1
Tight junction MPP5, RRAS2, VAPA, PPP2CB, KRAS miR-1, miR-23b-3p, miR-133b, miR-143-3p
Arrhythmogenic right ventricular cardiomyopathy (ARVC) GJA1, ITGA6, SGCB, ITGB8, ACTB, ACTG1 miR-1, miR-30c-5p, miR-145-5p