Skip to main content

Advertisement

Table 2 In vivo heart functional parameters of rats by echocardiography at 4 weeks

From: Up-regulation of heme oxygenase-1 after infarct initiation reduces mortality, infarct size and left ventricular remodeling: experimental evidence and proof of concept

Heart function Sham group MI group CoPP-MI group CoPP + SnMP MI group
n = 20 n = 35 n = 25 n = 6
LVEDd (mm) 5.5 ± 0.2 7.4 ± 0.4**# 6.3 ± 0.3* 8.5 ± 0.4**#
LVESd (mm) 2.0 ± 0.2 5.0 ± 0.3**# 2.9 ± 0.1 6.0 ± 0.4**#
EDAW (mm) 1.6 ± 0.1 1.1 ± 0.1**# 1.5 ± 0.1 1.1 ± 0.1**#
EDPW (mm) 1.6 ± 0.1 1.9 ± 0.1**# 1.6 ± 0.1 1.9 ± 0.7**#
SAWT% 71 ± 3 35 ± 2**# 60 ± 3* 38 ± 5**#
SPWT% 70 ± 2 41 ± 2**# 69 ± 2 52 ± 4**#
FS% 65 ± 3 34 ± 2**# 54 ± 2* 29 ± 3**#
HR 456 ± 7 495 ± 5**# 443 ± 6 470 ± 9#
  1. Values are mean ± SEM; n, number of animals tested; LVEDd, left ventricular end-diastole diameter; LVESd, left ventricular end-systole diameter; EDAW, end-diastole anterior wall thickness; EDPW, end-diastole posterior (remote) wall thickness; SAWT%, percent systolic anterior wall thickening; SPWT%, percent systolic posterior (remote) wall thickening; FS%. percent fractional shortening. HR, heart rate. *p < 0.05 and **p < 0.001 vs sham-operated; #p < 0.001 vs CoPP-treated infarct.