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Table 4 Relative risks of recurrence according to clinicopathological factors and PIGR expression in radically resected primary tumours (R0) and in curatively treated patients (R0 + M0)

From: Expression and prognostic significance of the polymeric immunoglobulin receptor in esophageal and gastric adenocarcinoma

   R0 resection R0 resection + M0
  n (events) Unadjusted HR (95% CI) p-value Adjusted HR (95% CI) p-value n (events) Unadjusted HR (95% CI) p-value Adjusted HR (95% CI) p-value
Age           
 Continuous 105 (46) 1.00 (0.98-1.03) 0.728 1.04 (1.01-1.08) 0.005 87 (35) 1.00 (0.97-1.03) 0.887 1.04 (1.00-1.07) 0.049
Gender           
 Female 20 (5) 1.00   1.00   16 (3) 1.00   1.00  
 Male 85 (41) 2.04 (0.81-5.18) 0.132 1.97 (0.73-5.36) 0.183 71 (32) 2.78 (0.85-9.07) 0.091 4.43 (1.21-16.24) 0.025
T-stage           
 T1 16 (3) 1.00   1.00   11 (1) 1.00   1.00  
 T2 28 (10) 2.32 (0.64-8.44) 0.201 1.78 (0.41-7.75) 0.440 24 (7) 3.66 (0.45-29.73) 0.225 2.45 (0.26-22.66) 0.430
 T3 48 (25) 3.71 (1.12-12.34) 0.032 1.90 (0.46-7.72) 0.372 43 (22) 7.21 (0.97-53.55) 0.053 3.07 (0.36-26.02) 0.304
 T4 12 (8) 6.50 (1.71-24.70) 0.006 2.07 (0.42-10.26) 0.372 8 (5) 11.29 (1.31-97.00) 0.027 4.50 (0.39-51.49) 0.226
N-stage           
 N0 41 (3) 1.00   1.00   37 (3) 1.00   1.00  
 N1 19 (11) 10.52 (2.92-37.85) <0.001 13.86 (3.72-51.70) <0.001 17 (10) 9.31 (2.56-33.87) 0.001 10.11 (2.61-39.22) 0.001
 N2 26 (16) 12.97 (3.77-44.67) <0.001 15.68 (4.44-55.41) <0.001 22 (3) 11.22 (3.19-39.52) <0.001 14.68 (3.85-55.92) <0.001
 N3 19 (16) 23.32 (6.75-80.56) <0.001 30.25 (8.48-107.93) <0.001 11 (9) 19.22 (5.13-71.98) <0.001 46.878 (10.56-208.038) <0.001
M-stage           
 M0 87 (35) 1.00   1.00    -   -  
 M1 7 (6) 4.17 (1.74-10.01) 0.001 2.26 (0.77-6.69) 0.139   -   -  
Differentiation           
 High-moderate 32 (9) 1.00   1.00   31 (9) 1.00   1.00  
 Low 55 (31) 2.31 (1.10-4.86) 0.027 2.59 (1.20-5.61) 0.016 39 (20) 1.91 (0.87-4.19) 0.108 1.20 (0.43-3.34) 0.727
Location           
 Esophagus 32 (12)      26 (8) 1.00    
 GE-junction 27 (15) 1.81 (0.84-3.89) 0.128 1.92 (0.80-4.64) 0.144 25 (13) 2.00 (1.83-0.83-4.84) 0.122 3.22 (1.19-8.75) 0.022
 Stomach 44 (19) 1.29 (0.63-2.67) 0.484 1.67 (0.66-4.26) 0.282 35 (14) 1.49 (0.63-3.56) 0.367 3.86 (1.35-11.03) 0.011
PIGR expression           
 Low 41 (25) 1.00   1.00   33 (21) 1.00   1.00  
 High 64 (21) 0.49 (0.27-0.88) 0.017 0.49 (0.27-0.90) 0.021 54 (14) 0.37 (0.19-0.72) 0.004 0.32 (0.15-0.69) 0.004