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Table 3 Relative risks of death according to clinicopathological factors and PIGR expression – entire cohort and curatively treated patients with radically resected primary tumours

From: Expression and prognostic significance of the polymeric immunoglobulin receptor in esophageal and gastric adenocarcinoma

  

Entire cohort

R0 resection

 

n (events)

Unadjusted HR (95% CI)

p-value

Adjusted HR (95% CI)

p-value

n (events)

Unadjusted HR (95% CI)

p-value

Adjusted HR (95% CI)

p-value

Age

          

 Continuous

173

1.03 (1.01-1.05)

<0.001

1.04 (1.03-1.06)

<0.001

120 (65)

1.05 (1.02-1.07)

<0.001

1.07 (1.04-1.09)

<0.001

Gender

          

 Female

41 (29)

1.00

 

1.00

 

26 (15)

1.00

 

1.00

 

 Male

132 (82)

0.75 (0.49-1.14)

0.177

1.16 (0.11-1.90)

0.544

94 (50)

0.85 (0.48-1.52)

0.584

1.05 (0.57-1.94)

0.882

T-stage

          

 T1

18 (5)

1.00

 

1.00

 

18 (5)

1.00

 

1.00

 

 T2

32 (17)

2.30 (0.85-6.25)

0.102

1.36 (0.47-3.88)

0.568

31 (17)

2.43 (0.89-6.60)

0.082

1.39 (0.46-4.26)

0.560

 T3

93 (66)

3.79 (1.52-9.44)

0.004

1.43 (0.51-3.96)

0.495

55 (34)

2.94 (1.15-7.53)

0.025

1.23 (0.40-3.72)

0.716

 T4

27 (21)

5.59 (2.09-14.90)

0.001

2.12 (0.72-6.28)

0.175

15 (9)

3.34 (1.11-9.99)

0.031

1.30 (0.34-4.96)

0.697

N-stage

          

 N0

58 (27)

1.00

 

1.00

 

46 (18)

1.00

 

1.00

 

 N1

29 (17)

1.41 (0.77-2.59)

0.266

1.61 (0.86-2.98)

0.133

22 (11)

1.40 (0.66-2.97)

0.380

1.95 (0.90-4.21)

0.089

 N2

41 (30)

2.06 (1.22-3.47)

0.007

2.28 (1.32-3.93)

0.003

27 (17)

2.03 (1.04-3.94)

0.037

3.02 (1.51-6.05)

0.002

 N3

45 (37)

3.22 (1.94-5.33)

<0.001

3.14 (1.81-5.45)

<0.001

25 (19)

3.45 (1.80-6.64)

<0.001

4.95 (2.46-9.93)

<0.001

M-stage

          

 M0

136 (83)

1.00

 

1.00

 

97 (50)

1.00

 

1.00

 

 M1

18 (16)

2.23 (1.30-3.82)

0.004

1.69 (0.95-3.00)

0.072

10 (9)

2.78 (1.36-5.67)

0.005

1.54 (0.67-3.53)

0.311

Differentiation

          

 High-moderate

46 (26)

1.00

 

1.00

 

37 (19)

1.00

 

1.00

 

 Low

102 (75)

1.50 (0.96-2.34)

0.077

1.36 (0.85-2.17)

0.204

65 (40)

1.23 (0.71-2.12)

0.466

1.42 (0.81-2.49)

0.226

Margins

          

 R0

123 (68)

1.00

 

1.00

  

1.00

 

1.00

 

 R1

31 (27)

2.75 (1.76-4.30)

<0.001

2.15 (1.34-3.46)

0.002

 

-

 

-

 

 R2

19 (16)

2.34 (1.35-4.07)

0.003

2.31 (1.30-4.11)

0.004

 

-

 

-

 

Location

          

 Esophagus

59 (33)

1.00

 

1.00

 

37 (16)

1.00

 

1.00

 

 GE-junction

45 (31)

1.32 (0.81-2.16)

0.266

1.51 (0.90-2.56)

0.120

30 (18)

1.44 (0.74-2.83)

0.286

1.26 (0.62-2.58)

0.523

 Stomach

65 (44)

1.26 (0.80-1.94)

0.311

1.59 (0.96-2.63)

0.069

50 (29)

1.44 (0.78-2.66)

0.237

1.41 (0.63-3.16)

0.409

PIGR expression

          

 Low

92 (66)

1.00

 

1.00

 

37 (58)

1.00

 

1.00

 

 High

81 (45)

0.69 (0.47-1.01)

0.056

1.00 (0.66-1.52)

0.992

28 (62)

0.58 (0.36-0.96)

0.032

0.60 (0.36-0.99)

0.044