Entire cohort | R0 resection | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
n (events) | Unadjusted HR (95% CI) | p-value | Adjusted HR (95% CI) | p-value | n (events) | Unadjusted HR (95% CI) | p-value | Adjusted HR (95% CI) | p-value | |
Age | ||||||||||
Continuous | 173 | 1.03 (1.01-1.05) | <0.001 | 1.04 (1.03-1.06) | <0.001 | 120 (65) | 1.05 (1.02-1.07) | <0.001 | 1.07 (1.04-1.09) | <0.001 |
Gender | ||||||||||
Female | 41 (29) | 1.00 | 1.00 | 26 (15) | 1.00 | 1.00 | ||||
Male | 132 (82) | 0.75 (0.49-1.14) | 0.177 | 1.16 (0.11-1.90) | 0.544 | 94 (50) | 0.85 (0.48-1.52) | 0.584 | 1.05 (0.57-1.94) | 0.882 |
T-stage | ||||||||||
T1 | 18 (5) | 1.00 | 1.00 | 18 (5) | 1.00 | 1.00 | ||||
T2 | 32 (17) | 2.30 (0.85-6.25) | 0.102 | 1.36 (0.47-3.88) | 0.568 | 31 (17) | 2.43 (0.89-6.60) | 0.082 | 1.39 (0.46-4.26) | 0.560 |
T3 | 93 (66) | 3.79 (1.52-9.44) | 0.004 | 1.43 (0.51-3.96) | 0.495 | 55 (34) | 2.94 (1.15-7.53) | 0.025 | 1.23 (0.40-3.72) | 0.716 |
T4 | 27 (21) | 5.59 (2.09-14.90) | 0.001 | 2.12 (0.72-6.28) | 0.175 | 15 (9) | 3.34 (1.11-9.99) | 0.031 | 1.30 (0.34-4.96) | 0.697 |
N-stage | ||||||||||
N0 | 58 (27) | 1.00 | 1.00 | 46 (18) | 1.00 | 1.00 | ||||
N1 | 29 (17) | 1.41 (0.77-2.59) | 0.266 | 1.61 (0.86-2.98) | 0.133 | 22 (11) | 1.40 (0.66-2.97) | 0.380 | 1.95 (0.90-4.21) | 0.089 |
N2 | 41 (30) | 2.06 (1.22-3.47) | 0.007 | 2.28 (1.32-3.93) | 0.003 | 27 (17) | 2.03 (1.04-3.94) | 0.037 | 3.02 (1.51-6.05) | 0.002 |
N3 | 45 (37) | 3.22 (1.94-5.33) | <0.001 | 3.14 (1.81-5.45) | <0.001 | 25 (19) | 3.45 (1.80-6.64) | <0.001 | 4.95 (2.46-9.93) | <0.001 |
M-stage | ||||||||||
M0 | 136 (83) | 1.00 | 1.00 | 97 (50) | 1.00 | 1.00 | ||||
M1 | 18 (16) | 2.23 (1.30-3.82) | 0.004 | 1.69 (0.95-3.00) | 0.072 | 10 (9) | 2.78 (1.36-5.67) | 0.005 | 1.54 (0.67-3.53) | 0.311 |
Differentiation | ||||||||||
High-moderate | 46 (26) | 1.00 | 1.00 | 37 (19) | 1.00 | 1.00 | ||||
Low | 102 (75) | 1.50 (0.96-2.34) | 0.077 | 1.36 (0.85-2.17) | 0.204 | 65 (40) | 1.23 (0.71-2.12) | 0.466 | 1.42 (0.81-2.49) | 0.226 |
Margins | ||||||||||
R0 | 123 (68) | 1.00 | 1.00 | 1.00 | 1.00 | |||||
R1 | 31 (27) | 2.75 (1.76-4.30) | <0.001 | 2.15 (1.34-3.46) | 0.002 | - | - | |||
R2 | 19 (16) | 2.34 (1.35-4.07) | 0.003 | 2.31 (1.30-4.11) | 0.004 | - | - | |||
Location | ||||||||||
Esophagus | 59 (33) | 1.00 | 1.00 | 37 (16) | 1.00 | 1.00 | ||||
GE-junction | 45 (31) | 1.32 (0.81-2.16) | 0.266 | 1.51 (0.90-2.56) | 0.120 | 30 (18) | 1.44 (0.74-2.83) | 0.286 | 1.26 (0.62-2.58) | 0.523 |
Stomach | 65 (44) | 1.26 (0.80-1.94) | 0.311 | 1.59 (0.96-2.63) | 0.069 | 50 (29) | 1.44 (0.78-2.66) | 0.237 | 1.41 (0.63-3.16) | 0.409 |
PIGR expression | ||||||||||
Low | 92 (66) | 1.00 | 1.00 | 37 (58) | 1.00 | 1.00 | ||||
High | 81 (45) | 0.69 (0.47-1.01) | 0.056 | 1.00 (0.66-1.52) | 0.992 | 28 (62) | 0.58 (0.36-0.96) | 0.032 | 0.60 (0.36-0.99) | 0.044 |