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Table 3 Relative risks of death according to clinicopathological factors and PIGR expression – entire cohort and curatively treated patients with radically resected primary tumours

From: Expression and prognostic significance of the polymeric immunoglobulin receptor in esophageal and gastric adenocarcinoma

   Entire cohort R0 resection
  n (events) Unadjusted HR (95% CI) p-value Adjusted HR (95% CI) p-value n (events) Unadjusted HR (95% CI) p-value Adjusted HR (95% CI) p-value
Age           
 Continuous 173 1.03 (1.01-1.05) <0.001 1.04 (1.03-1.06) <0.001 120 (65) 1.05 (1.02-1.07) <0.001 1.07 (1.04-1.09) <0.001
Gender           
 Female 41 (29) 1.00   1.00   26 (15) 1.00   1.00  
 Male 132 (82) 0.75 (0.49-1.14) 0.177 1.16 (0.11-1.90) 0.544 94 (50) 0.85 (0.48-1.52) 0.584 1.05 (0.57-1.94) 0.882
T-stage           
 T1 18 (5) 1.00   1.00   18 (5) 1.00   1.00  
 T2 32 (17) 2.30 (0.85-6.25) 0.102 1.36 (0.47-3.88) 0.568 31 (17) 2.43 (0.89-6.60) 0.082 1.39 (0.46-4.26) 0.560
 T3 93 (66) 3.79 (1.52-9.44) 0.004 1.43 (0.51-3.96) 0.495 55 (34) 2.94 (1.15-7.53) 0.025 1.23 (0.40-3.72) 0.716
 T4 27 (21) 5.59 (2.09-14.90) 0.001 2.12 (0.72-6.28) 0.175 15 (9) 3.34 (1.11-9.99) 0.031 1.30 (0.34-4.96) 0.697
N-stage           
 N0 58 (27) 1.00   1.00   46 (18) 1.00   1.00  
 N1 29 (17) 1.41 (0.77-2.59) 0.266 1.61 (0.86-2.98) 0.133 22 (11) 1.40 (0.66-2.97) 0.380 1.95 (0.90-4.21) 0.089
 N2 41 (30) 2.06 (1.22-3.47) 0.007 2.28 (1.32-3.93) 0.003 27 (17) 2.03 (1.04-3.94) 0.037 3.02 (1.51-6.05) 0.002
 N3 45 (37) 3.22 (1.94-5.33) <0.001 3.14 (1.81-5.45) <0.001 25 (19) 3.45 (1.80-6.64) <0.001 4.95 (2.46-9.93) <0.001
M-stage           
 M0 136 (83) 1.00   1.00   97 (50) 1.00   1.00  
 M1 18 (16) 2.23 (1.30-3.82) 0.004 1.69 (0.95-3.00) 0.072 10 (9) 2.78 (1.36-5.67) 0.005 1.54 (0.67-3.53) 0.311
Differentiation           
 High-moderate 46 (26) 1.00   1.00   37 (19) 1.00   1.00  
 Low 102 (75) 1.50 (0.96-2.34) 0.077 1.36 (0.85-2.17) 0.204 65 (40) 1.23 (0.71-2.12) 0.466 1.42 (0.81-2.49) 0.226
Margins           
 R0 123 (68) 1.00   1.00    1.00   1.00  
 R1 31 (27) 2.75 (1.76-4.30) <0.001 2.15 (1.34-3.46) 0.002   -   -  
 R2 19 (16) 2.34 (1.35-4.07) 0.003 2.31 (1.30-4.11) 0.004   -   -  
Location           
 Esophagus 59 (33) 1.00   1.00   37 (16) 1.00   1.00  
 GE-junction 45 (31) 1.32 (0.81-2.16) 0.266 1.51 (0.90-2.56) 0.120 30 (18) 1.44 (0.74-2.83) 0.286 1.26 (0.62-2.58) 0.523
 Stomach 65 (44) 1.26 (0.80-1.94) 0.311 1.59 (0.96-2.63) 0.069 50 (29) 1.44 (0.78-2.66) 0.237 1.41 (0.63-3.16) 0.409
PIGR expression           
 Low 92 (66) 1.00   1.00   37 (58) 1.00   1.00  
 High 81 (45) 0.69 (0.47-1.01) 0.056 1.00 (0.66-1.52) 0.992 28 (62) 0.58 (0.36-0.96) 0.032 0.60 (0.36-0.99) 0.044