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Table 1 Patient characteristics and association of CD8+ cells (intra- and peri-tumoral) with clinicopathological data (max n = 130)

From: CD8/CD45RO T-cell infiltration in endoscopic biopsies of colorectal cancer predicts nodal metastasis and survival

Feature    CD8i N (%) CD8s N (%)   
   N (%) Low High P-value Low High P-value
Age (years) (n = 130) Median (min, max) 72 (30-91) 71.4 (30-91) 73.8 (50-90) 0.3872 72.4 (30-91) 71 (30-90) 0.876
Gender (n = 130) Male 80 (61.5) 61 (61.0) 19 (63.3) 1.0 40 (61.5) 40 (61.5) 1.0
  Female 50 (38.5) 39 (39.0) 11 (36.7)   25 (38.5) 25 (38.5)  
Histological subtype (n = 130) Non-mucinous 106 (81.5) 80 (80.0) 26 (86.7) 0.5923 49 (75.4) 57 (87.7) 0.1123
  Mucinous 24 (18.5) 20 (20.0) 4 (13.3)   16 (24.6) 8 (12.3)  
Tumour location (n = 129) Left 43 (33.3) 33 (33.3) 10 (33.3) 0.8606 21 (32.3) 22 (34.4) 0.7333
  Rectum 30 (23.3) 22 (22.2) 8 (26.7)   17 (26.2) 13 (20.3)  
  Right 56 (43.4) 44 (44.4) 12 (40.0)   27 (41.5) 29 (45.3)  
pT (n = 130) pT1 + pT2 30 (23.1) 15 (15.0) 15 (50.0) <0.0001 12 (18.5) 18 (27.7) 0.2979
  pT3 + pT4 100 (76.9) 85 (85.0) 15 (50.0)   53 (81.5) 47 (72.3)  
pN (n = 130) pN0 54 (41.5) 34 (34.0) 20 (66.7) 0.0015 26 (40.0) 28 (43.1) 0.8588
  pN1-2 76 (58.5) 66 (66.0) 10 (33.3)   39 (60.0) 37 (56.9)  
cT (n = 30) cT1-2 9 (31.0) 6 (27.3) 3 (42.9) 0.6424 5 (45.5) 4 (22.2) 0.2371
  cT3-4 20 (69.0) 16 (72.7) 4 (57.1)   6 (54.6) 14 (77.8)  
cN (n = 113) cN0 68 (62.4) 50 (59.5) 18 (72.0) 0.2583 32 (57.1) 36 (67.9) 0.3229
  cN1-2 41 (37.6) 34 (40.5) 7 (28.0)   24 (42.9) 17 (32.1)  
No. LN collected (n = 130) Median (min, max) 22 (4-73) 23.0 (6-67) 16.5 (4-73) 0.0842 23.0 (4-67) 18 (6-73) 0.1369
Tumour deposits (n = 108) 0 91 (84.3) 67 (79.8) 24 (100.0) 0.0117 42 (82.4) 49 (86.0) 0.792
  ≥1 17 (15.7) 17 (20.2) 0 (0.0)   9 (17.7) 8 (14.0)  
Metastasis (n = 123) cM0 86 (69.9) 63 (67.0) 23 (79.3) 0.2519 42 (68.8) 44 (71.0) 0.8457
  cM1 37 (30.1) 31 (33.0) 6 (20.7)   19 (31.2) 18 (29.0)  
Lymphatic invasion (n = 113) L0 29 (25.7) 17 (19.3) 12 (48.0) 0.008 10 (18.5) 19 (32.2) 0.1312
  L1 84 (74.3) 71 (80.7) 13 (53.0)   44 (81.5) 40 (67.8)  
Venous invasion (n = 114) V0 57 (50.0) 39 (44.3) 18 (69.2) 0.0433 26 (47.3) 31 (52.5) 0.708
  V1-2 57 (50.0) 49 (55.7) 8 (30.8)   29 (52.7) 28 (47.5)  
Perineural invasion (n = 111) Pn0 100 (90.1) 75 (87.2) 25 (100.0) 0.0671 48 (90.6) 52 (89.7) 1.0
  Pn1 11 (9.1) 11 (12.8) 0 (0.0)   5 (9.4) 6 (10.3)  
Tumour grade (n = 130) G1-2 85 (65.4) 66 (66.0) 19 (63.3) 0.8286 40 (61.5) 45 (69.2) 0.3566
  G3 45 (34.6) 34 (34.0) 11 (36.7)   25 (38.5) 20 (30.8)  
Postoperative therapy (n = 127) None 88 (69.3) 65 (66.3) 23 (79.3) 0.2524 41 (64.1) 47 (74.6) 0.2491
  Yes 39 (30.7) 33 (33.7) 6 (20.7)   23 (36.0) 16 (25.4)  
MMR status (n = 117) Proficient 99 (84.6) 77 (85.6) 22 (81.5) 0.5596 52 (89.7) 47 (79.7) 0.1996
  Deficient 18 (15.4) 13 (14.4) 5 (18.5)   6 (10.3) 12 (20.3)  
Survival time (n = 76) Median (95% CI) months 73.5 (29-105) 53.1 (22.6-73.9) Not reached 0.0026 26.4 (13.7-73.5) 105.4 (54.9-NE) 0.0053