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Figure 4 | Journal of Translational Medicine

Figure 4

From: Time-restricted feeding and the realignment of biological rhythms: translational opportunities and challenges

Figure 4

Robust circadian entrainment characterizes homeostasis, whereas disruptions (amplitude and phase) characterize stressful critical conditions. Whereas in homeostasis circadian rhythms are properly aligned with clearly identifiable phase locking, circadian disruption shifts peripheral clock rhythms. Restoration of peripheral rhythms, including nutritionally-driven metabolic rhythms through time-restricted feeding will re-entrain the system and provide appropriate systemic cues.

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